The GIMAP Family Proteins: An Incomplete Puzzle

被引：32
作者：
Limoges, Marc-Andre
Cloutier, Maryse
Nandi, Madhuparna
Ilangumaran, Subburaj
Ramanathan, Sheela [1 ]
机构：
[1] Univ Sherbrooke, Dept Immunol & Cell Biol, Fac Med & Hlth Sci, Sherbrooke, PQ, Canada
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
GIMAP5; gimap; lymphopenia; AIG domain; T lymphocyte; B cells; T-CELL-RECEPTOR; MITOCHONDRIAL-DNA SEGREGATION; RECENT THYMIC EMIGRANTS; BB-RAT; RYANODINE RECEPTOR; IMMUNE-RESPONSES; ENDOPLASMIC-RETICULUM; POSITIVE SELECTION; DIABETES-MELLITUS; ADOPTIVE TRANSFER;
D O I：
10.3389/fimmu.2021.679739
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Overview: Long-term survival of T lymphocytes in quiescent state is essential to maintain their cell numbers in secondary lymphoid organs and in peripheral circulation. In the BioBreeding diabetes-prone strain of rats (BB-DP), loss of functional GIMAP5 (GTPase of the immune associated nucleotide binding protein 5) results in profound peripheral T lymphopenia. This discovery heralded the identification of a new family of proteins initially called Immune-associated nucleotide binding protein (IAN) family. In this review we will use 'GIMAP' to refer to this family of proteins. Recent studies suggest that GIMAP proteins may interact with each other and also be involved in the movement of the cellular cargo along the cytoskeletal network. Here we will summarize the current knowledge on the characteristics and functions of GIMAP family of proteins.
引用
收藏
页数：15
相关论文
共 154 条
[1]   Molecular pathogenesis of T-cell leukaemia and lymphoma [J].
Aifantis, Iannis ;
Raetz, Elizabeth ;
Buonamici, Silvia .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :380-390
[2]   Loss of Immunological Tolerance in Gimap5-Deficient Mice Is Associated with Loss of Foxo in CD4+ T Cells [J].
Aksoylar, H. Ibrahim ;
Lampe, Kristin ;
Barnes, Michael J. ;
Plas, David R. ;
Hoebe, Kasper .
JOURNAL OF IMMUNOLOGY, 2012, 188 (01) :146-154
[3]   Proteasomal degradation of the Fox01 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins [J].
Aoki, M ;
Hao, J ;
Vogt, PK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (37) :13613-13617
[4]   PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].
ASHTONRICKARDT, PG ;
VANKAER, L ;
SCHUMACHER, TNM ;
PLOEGH, HL ;
TONEGAWA, S .
CELL, 1993, 73 (05) :1041-1049
[5]   Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections [J].
Balla, Keir M. ;
Rice, Marlen C. ;
Gagnon, James A. ;
Elde, Nels C. .
CURRENT BIOLOGY, 2020, 30 (11) :2092-+
[6]   Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice [J].
Barnes, Michael J. ;
Aksoylar, Halil ;
Krebs, Philippe ;
Bourdeau, Tristan ;
Arnold, Carrie N. ;
Xia, Yu ;
Khovananth, Kevin ;
Engel, Isaac ;
Sovath, Sosathya ;
Lampe, Kristin ;
Laws, Eleana ;
Saunders, Amy ;
Butcher, Geoffrey W. ;
Kronenberg, Mitchell ;
Steinbrecher, Kris ;
Hildeman, David ;
Grimes, H. Leighton ;
Beutler, Bruce ;
Hoebe, Kasper .
JOURNAL OF IMMUNOLOGY, 2010, 184 (07) :3743-3754
[7]   Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides [J].
Battersby, BJ ;
Redpath, ME ;
Shoubridge, EA .
HUMAN MOLECULAR GENETICS, 2005, 14 (17) :2587-2594
[8]   Nuclear genetic control of mitochondrial DNA segregation [J].
Battersby, BJ ;
Loredo-Osti, JC ;
Shoubridge, EA .
NATURE GENETICS, 2003, 33 (02) :183-186
[9]   Selection of a mtDNA sequence variant in hepatocytes of heteroplasmic mice is not due to differences in respiratory chain function or efficiency of replication [J].
Battersby, BJ ;
Shoubridge, EA .
HUMAN MOLECULAR GENETICS, 2001, 10 (22) :2469-2479
[10]   The genetics and mechanisms of T cell acute lymphoblastic leukaemia [J].
Belver, Laura ;
Ferrando, Adolfo .
NATURE REVIEWS CANCER, 2016, 16 (08) :494-507
12345678910