Inhibition of HIV-1 by the C-chemokine XCL1/Lymphotactin is dependent on high affinity binding to glycosaminoglycans (GAG)

被引：0
|
作者：
Guzzo, Christina [1 ]
Fox, Jamie [2 ]
Lin, Yin [1 ]
Volkman, Brian [2 ]
Lusso, Paolo [1 ]
Miao, Huiyi [1 ]
机构：
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD USA
[2] Med Coll Wisconsin, Dept Biochem, Madison, WI USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 67卷
关键词：
D O I：
10.1097/01.qai.0000456193.00905.5d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P-D4
引用
收藏
页码：88 / 88
页数：1
相关论文
共 50 条
  • [1] Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation
    Fox, Jamie C.
    Tyler, Robert C.
    Guzzo, Christina
    Tuinstra, Robbyn L.
    Peterson, Francis C.
    Lusso, Paolo
    Volkman, Brian F.
    ACS CHEMICAL BIOLOGY, 2015, 10 (11) : 2580 - 2588
  • [2] The CD8-Derived Chemokine XCL1/Lymphotactin Is a Conformation-Dependent, Broad-Spectrum Inhibitor of HIV-1
    Guzzo, Christina
    Fox, Jamie
    Lin, Yin
    Miao, Huiyi
    Cimbro, Raffaello
    Volkman, Brian F.
    Fauci, Anthony S.
    Lusso, Paolo
    PLOS PATHOGENS, 2013, 9 (12): : 1 - 11
  • [3] Origins of metamorphic folding in the human chemokine XCL1/lymphotactin
    Volkman, Brian
    Tyler, Robert
    Fox, Jamie
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [4] Expression and Function of the C-Class Chemokine Lymphotactin (XCL1) in Wegener's Granulomatosis
    Blaschke, Sabine
    Brandt, Philip
    Wessels, Johannes T.
    Mueller, Gerhard A.
    JOURNAL OF RHEUMATOLOGY, 2009, 36 (11) : 2491 - 2500
  • [5] Expression and functional role of the C-class chemokine lymphotactin (XCL1) in Wegener's granulomatosis
    Blaschke, Sabine
    Brandt, Philip
    Wessels, Johannes
    Mueller, Gerhard A.
    ARTHRITIS AND RHEUMATISM, 2008, 58 (09): : S663 - S663
  • [6] An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity
    Tuinstra, Robbyn L.
    Peterson, Francis C.
    Elgin, E. Sonay
    Pelzek, Adam J.
    Volkman, Brian F.
    BIOCHEMISTRY, 2007, 46 (10) : 2564 - 2573
  • [7] The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation
    Leiter, Odette
    Bernas, Stefanie N.
    Seidemann, Suse
    Overall, Rupert W.
    Horenburg, Cindy
    Kowal, Susann
    Kempermann, Gerd
    Walker, Tara L.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [8] The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation
    Odette Leiter
    Stefanie N. Bernas
    Suse Seidemann
    Rupert W. Overall
    Cindy Horenburg
    Susann Kowal
    Gerd Kempermann
    Tara L. Walker
    Scientific Reports, 9
  • [9] MYRISTOYLATION-DEPENDENT BINDING OF HIV-1 GAG PROTEINS TO CELLULAR MEMBRANES
    SPEARMAN, PW
    RATNER, L
    CLINICAL RESEARCH, 1993, 41 (02): : A395 - A395
  • [10] A high affinity binding site for the HIV-1 nucleocapsid protein
    Berglund, JA
    Charpentier, B
    Rosbash, M
    NUCLEIC ACIDS RESEARCH, 1997, 25 (05) : 1042 - 1049
12345