Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases

被引：29
作者：
Ling, Ye [1 ]
Wang, Jian [1 ]
Wang, Lingyan [1 ]
Hou, Jiayun [1 ]
Qian, Peiyu [1 ]
Wang Xiang-dong [1 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Clin Bioinformat, Ctr Clin Bioinformat, Shanghai 200433, Peoples R China
来源：
CANCER AND METASTASIS REVIEWS | 2015年 / 34卷 / 02期
关键词：
Carcinoembryonic antigen-related cell adhesion molecule 1; Non-small cell lung carcinoma; Chronic obstructive pulmonary disease; Proliferation; Angiogenesis; Apoptosis; Metastasis; NONTYPABLE HAEMOPHILUS-INFLUENZAE; CARCINOEMBRYONIC ANTIGEN FAMILY; OBSTRUCTIVE PULMONARY-DISEASE; BILIARY GLYCOPROTEIN CD66A; SHORT CYTOPLASMIC DOMAIN; ADHESION MOLECULE-1; MORAXELLA-CATARRHALIS; ELEVATED EXPRESSION; MONOCLONAL-ANTIBODY; MELANOMA-CELLS;
D O I：
10.1007/s10555-015-9569-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a broadly-expressed immunoglobulin-like cell adhesion molecule with a wide range of biological functions to regulate cell signaling. The present article mainly focuses on the role of CEACAM1 as a therapeutic target in lung diseases and discusses the potential of therapeutic strategies targeting CEACAM1. The article overviews the structure and its sub-types, biological function, and potential roles of CEACAM1 in lung diseases. Alterations of CEACAM1 expression and CEACAM1-S/CEACAM1-L ratio promote the growth and metastasis of non-small cell lung carcinoma (NSCLC). Moreover, CEACAM1 mediates bacterial adherence and transcellular transcytosis, resulting in the suppression of immune cell activities and inflammatory responses, which may trigger acute exacerbation of chronic obstructive pulmonary disease (AECOPD). CEACAM1 plays a critical role in the development of NSCLC and AECOPD and can be a diagnostic biomarker and therapeutic target in lung diseases.
引用
收藏
页码：347 / 357
页数：11
相关论文
共 79 条
[1]   CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation [J].
Abou-Rjaily, GA ;
Lee, SJ ;
May, D ;
Al-Share, QY ;
DeAngelis, AM ;
Ruch, RJ ;
Neumaier, M ;
Kalthoff, H ;
Lin, SH ;
Najjar, SM .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (07) :944-952
[2]  
Al Olayan Ashwaq, 2012, J Infect Public Health, V5 Suppl 1, pS50, DOI 10.1016/j.jiph.2012.09.004
[3]   Novel therapeutic targets in non-small cell lung cancer [J].
Alamgeer, Muhammad ;
Ganju, Vinod ;
Watkins, D. Neil .
CURRENT OPINION IN PHARMACOLOGY, 2013, 13 (03) :394-401
[4]   Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer [J].
Arabzadeh, A. ;
Chan, C. ;
Nouvion, A-L ;
Breton, V. ;
Benlolo, S. ;
DeMarte, L. ;
Turbide, C. ;
Brodt, P. ;
Ferri, L. ;
Beauchemin, N. .
ONCOGENE, 2013, 32 (07) :849-860
[5]   Stromal CEACAM1 expression regulates colorectal cancer metastasis [J].
Arabzadeh, Azadeh ;
Beauchemin, Nicole .
ONCOIMMUNOLOGY, 2012, 1 (07) :1205-1207
[6]   Notch Signaling in CD66+ Cells Drives the Progression of Human Cervical Cancers [J].
Bajaj, Jeevisha ;
Maliekal, Tessy Thomas ;
Vivien, Eric ;
Pattabiraman, Chitra ;
Srivastava, Sweta ;
Krishnamurthy, H. ;
Giri, V. ;
Subramanyam, Deepa ;
Krishna, Sudhir .
CANCER RESEARCH, 2011, 71 (14) :4888-4897
[7]   Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis [J].
Beauchemin, Nicole ;
Arabzadeh, Azadeh .
CANCER AND METASTASIS REVIEWS, 2013, 32 (3-4) :643-671
[8]   Role of maspin in cancer [J].
Berardi, Rossana ;
Morgese, Francesca ;
Onofri, Azzurra ;
Mazzanti, Paola ;
Pistelli, Mirco ;
Ballatore, Zelmira ;
Savini, Agnese ;
De Lisa, Mariagrazia ;
Caramanti, Miriam ;
Rinaldi, Silvia ;
Pagliaretta, Silvia ;
Santoni, Matteo ;
Pierantoni, Chiara ;
Cascinu, Stefano .
CLINICAL AND TRANSLATIONAL MEDICINE, 2013, 2
[9]   Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC) [J].
Berger, CN ;
Billker, O ;
Meyer, TF ;
Servin, AL ;
Kansau, I .
MOLECULAR MICROBIOLOGY, 2004, 52 (04) :963-983
[10]   A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin [J].
Bookwalter, James E. ;
Jurcisek, Joseph A. ;
Gray-Owen, Scott D. ;
Fernandez, Soledad ;
McGillivary, Glen ;
Bakaletz, Lauren O. .
INFECTION AND IMMUNITY, 2008, 76 (01) :48-55
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