Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-α

被引：5
|
作者：
Reveneau, S
Paumelle, R
Deheuninck, J
Leroy, C
De Launoit, Y
Fafeur, V
机构：
[1] EPHE, INSERM, U517, F-21079 Dijon, France
[2] Inst Pasteur, CNRS, Unite Mixte Rech 8117, Inst Biol Lille, F-59021 Lille, France
来源：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷
关键词：
hepatocyte growth factor; scatter factor; JNK; tumor necrosis factor-alpha;
D O I：
10.1196/annals.1299.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.
引用
收藏
页码：100 / 103
页数：4
相关论文
共 50 条
  • [21] ERK-1 MAP Kinase Prevents TNF-Induced Apoptosis Through Bad Phosphorylation and Inhibition of Bax Translocation in HeLa Cells
    Pucci, Bruna
    Indelicato, Manuela
    Paradisi, Valentina
    Reali, Valentina
    Pellegrini, Laura
    Aventaggiato, Michele
    Karpinich, Natalie O.
    Fini, Massimo
    Russo, Matteo A.
    Farber, John L.
    Tafani, Marco
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 108 (05) : 1166 - 1174
  • [22] TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy
    Zhang, Jie
    Su, Yi-Min
    Li, Dai
    Cui, Yu
    Huang, Zhen-Zhen
    Wei, Jia-You
    Xue, Zi
    Pang, Rui-Ping
    Liu, Xian-Guo
    Xin, Wen-Jun
    BRAIN BEHAVIOR AND IMMUNITY, 2014, 38 : 185 - 191
  • [23] Inhibition of tumor necrosis factor-α (TNF-α)/TNF-α receptor binding by structural analogues of suramin
    Mancini, F
    Toro, CM
    Mabilia, M
    Giannangeli, M
    Pinza, M
    Milanese, C
    BIOCHEMICAL PHARMACOLOGY, 1999, 58 (05) : 851 - 859
  • [24] JNK1-mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF-α-induced apoptosis of HeLa cells
    Park, Byoungduck
    MOLECULAR MEDICINE REPORTS, 2014, 10 (06) : 3205 - 3210
  • [25] Iguratimod decreases bleomycin-induced pulmonary fibrosis in association with inhibition of TNF-α in mice
    Shao, Siqi
    Qu, Ziye
    Liang, Yiwen
    Xu, Yan
    Zhou, Dongmei
    Li, Danhua
    Zhang, Ying
    Yin, Songlou
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 99
  • [26] Induction of apoptosis by particulate matter:: role of TNF-α and MAPK
    Chin, BY
    Choi, ME
    Burdick, MD
    Strieter, RM
    Risby, TH
    Choi, AMK
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1998, 275 (05) : L942 - L949
  • [27] Knockdown of Ror2 suppresses TNF-α-induced inflammation and apoptosis in vascular endothelial cells
    Yang, Xiaohu
    Zhao, Suming
    Yuan, Hongxin
    Shi, Rongfeng
    Gu, Weiwei
    Gu, Zhuxin
    Lu, Xiaohua
    Zhao, Hui
    MOLECULAR MEDICINE REPORTS, 2020, 22 (04) : 2981 - 2989
  • [28] IFN-γ prevents TNF-α-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-κB activity
    Tolosa, L
    Morlá, M
    Iglesias, A
    Busquets, X
    Lladó, J
    Olmos, G
    CELLULAR SIGNALLING, 2005, 17 (11) : 1333 - 1342
  • [29] JNK activation is critical for Aplidin™-induced apoptosis
    Ana Cuadrado
    Laura González
    Yajaira Suárez
    Teresa Martínez
    Alberto Muñoz
    Oncogene, 2004, 23 : 4673 - 4680
  • [30] JNK activation is critical for Aplidin™-induced apoptosis
    Cuadrado, A
    González, L
    Suárez, Y
    Martínez, T
    Muñoz, A
    ONCOGENE, 2004, 23 (27) : 4673 - 4680
12345