Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-α

被引：5
|
作者：
Reveneau, S
Paumelle, R
Deheuninck, J
Leroy, C
De Launoit, Y
Fafeur, V
机构：
[1] EPHE, INSERM, U517, F-21079 Dijon, France
[2] Inst Pasteur, CNRS, Unite Mixte Rech 8117, Inst Biol Lille, F-59021 Lille, France
来源：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷
关键词：
hepatocyte growth factor; scatter factor; JNK; tumor necrosis factor-alpha;
D O I：
10.1196/annals.1299.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.
引用
收藏
页码：100 / 103
页数：4
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