Spectroscopic, kinetic and cytotoxic in vitro study of hexafluoroglutarate platinum(II) complex with 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

被引：16

作者：

Lakomska, Iwona ^{[1
]}

Hoffmann, Kamil ^{[1
]}

Topolski, Adrian ^{[1
]}

Kloskowski, Tomasz ^{[2
]}

Drewa, Tomasz ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ, Fac Chem, PL-87100 Torun, Poland

[2] Nicolaus Copernicus Univ, Chair Med Biol, PL-85092 Bydgoszcz, Poland

来源：

INORGANICA CHIMICA ACTA | 2012年 / 387卷

关键词：

Platinum(II) complex; Dicarboxylate; Triazolopyrimidine; Hydrolysis; Cytotoxicity in vitro; ANTITUMOR-ACTIVITY; MOLECULAR-STRUCTURE; CISPLATIN ANALOGS;

D O I：

10.1016/j.ica.2012.01.034

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of cis-[PtI2(dmtp)(2)] (where dmtp - 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) with silver hexafluoroglutarate [Ag-2(C5F6O4)] yielded new complex [Pt(C5F6O4)(dmtp)(2)]center dot 2H(2)O. The platinum(II) complex has been characterized by H-1, F-19 NMR and IR. In additional, kinetics of its hydrolysis and anti-proliferative activity in vitro against three cell lines (A549 human non small cell lung carcinoma; A375.S2 human melanoma and mouse B16 melanoma tumors) has been studied. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：455 / 459

页数：5

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