Genipin crosslinked curcumin loaded chitosan/montmorillonite K-10 (MMT) nanoparticles for controlled drug delivery applications

被引：36

作者：

Khatun, Bably ^{[1
]}

Banik, Nibedita ^{[1
]}

Hussain, Anowar ^{[2
]}

Ramteke, Anand ^{[3
]}

Maji, Tarun ^{[1
]}

机构：

[1] Tezpur Univ, Dept Chem Sci, Napaam, India

[2] Inst Adv Studies Sci & Technol, Div Biol Sci, Gauhati, India

[3] Tezpur Univ, Dept Mol Biol & Biotechnol, Napaam, India

来源：

JOURNAL OF MICROENCAPSULATION | 2018年 / 35卷 / 05期

关键词：

Drug delivery; controlled release; nanoparticles; chitosan; MMT; genipin; CHITOSAN-MONTMORILLONITE NANOPARTICLES; CONTROLLED-RELEASE; MICROSPHERES; ANTICANCER; CANCER; PROLIFERATION; ENCAPSULATION; SYSTEMS;

D O I：

10.1080/02652048.2018.1524524

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Here, we have reported the influence of MMT and genipin in releasing curcumin from the Genipin crosslinked Chitosan/MMT nanoparticles, prepared by ionic gelation method. The nanoparticles were characterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometry (XRD), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). Zeta potential and average diameter of the nanoparticles were found in the range 32-47 mV and 430-560nm. Swelling and release of curcumin from the nanoparticles increased with the decrease in pH of the medium, MMT, and genipin content. Curcumin released from the nanoparticles reduced the viability of MCF-7 and Hep G2 cells as compared to untreated cells. The nanoparticles increased the level of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase level in human PBMCs and decreased the level of Lipid peroxidation suggesting an enhanced protection against cellular damage. Lower pH and higher MMT concentration in the nanoparticles improved the mucoadhesive properties.

引用

页码：439 / 453

页数：15

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