Investigating Hydroxyl Chemical Exchange Using a Variable Saturation Power Chemical Exchange Saturation Transfer (vCEST) Method at 3 T

被引:5
作者
Clark, Daniel James [1 ,2 ,3 ]
Smith, Alex K. [4 ,5 ]
Dortch, Richard D. [4 ,5 ,6 ]
Knopp, Michael V. [1 ,2 ]
Smith, Seth A. [4 ,5 ,6 ]
机构
[1] Ohio State Univ, Dept Radiol, Columbus, OH 43210 USA
[2] Ohio State Univ, Wright Ctr Innovat, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA
[4] Vanderbilt Univ, Inst Imaging Sci, 1161 21st Ave South,AAA 3121 MCN, Nashville, TN 37232 USA
[5] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
[6] Vanderbilt Univ, Dept Radiol & Radiol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA
关键词
chemical exchange; cartilage; glycosaminoglycan; glycogen; glucose; endogenous contrast; AMIDE PROTON-TRANSFER; NUCLEAR OVERHAUSER ENHANCEMENT; MAGNETIZATION-TRANSFER; TRANSFER CEST; HUMAN BRAIN; IN-VIVO; QUANTITATIVE DESCRIPTION; WATER SATURATION; CONTRAST AGENTS; TRANSFER MRI;
D O I
10.1002/mrm.25987
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To develop a chemical exchange saturation transfer (CEST) scheme sensitive to hydroxyl protons at 3 T. Clinical imaging of hydroxyl moieties can have an impact on osteoarthritis, neuropsychiatric disorders, and cancer. Theory: By varying saturation amplitude linearly with frequency offset, the direct water saturation component of the Z-spectrum is flattened and can be subtracted to produce amagnetization transfer ratio difference spectrum (MTRdiff) that isolates solute resonances. Variable saturation power allows for near optimization of hydroxyl and amine/amide moieties in one Z-spectrum. Methods: Phantom studies were used to test vCEST performance in two environments: (1) aqueous single-solute (glycogen, glucose); (2) aqueous multiple solute (glycogen with bovine serum albumin). In vivo vCEST imaging of glycosaminoglycan content in patellar-femoral cartilage was performed in a subject with history of cartilage transplant. Results: In solutions with overlapping resonances, vCEST resolves separate hydroxyl and amine/amide peaks. CEST hydroxyl signal in cartilage is negligible, but with vCEST, hydroxyl signal ranged from 2 to 5% ppm and showed distinct contrast between lesions and normal appearing cartilage. Conclusion: Introduced a variable saturation amplitude CEST (vCEST) scheme to improve sensitivity to exchangeable hydroxyl moieties at 3 T resulting in detection of hydroxyl in the presence of multiple solutes with overlapping resonances. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:826 / 837
页数:12
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