Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

被引：193

作者：

Denk, Franziska ^{[1
]}

McMahon, Stephen B. ^{[1
]}

机构：

[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England

来源：

NEURON | 2012年 / 73卷 / 03期

基金：

英国惠康基金;

关键词：

HISTONE DEACETYLASE INHIBITORS; REGULATES MEMORY FORMATION; CPG-BINDING PROTEIN-2; LOW-BACK-PAIN; NEUROPATHIC PAIN; SPINAL-CORD; INFLAMMATORY PAIN; DNA METHYLATION; DORSAL-HORN; CENTRAL SENSITIZATION;

D O I：

10.1016/j.neuron.2012.01.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epigenetic processes, such as histone modifications and DNA methylation, have been associated with many neural functions including synaptic plasticity, learning, and memory. Here, we critically examine emerging evidence linking epigenetic mechanisms to the development or maintenance of chronic pain states. Although in its infancy, research in this area potentially unifies several pathophysiological processes underpinning abnormal pain processing and opens up a different avenue for the development of novel analgesics.

引用

页码：435 / 444

页数：10

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