Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

被引：22

作者：

Chen, Zhihong ^{[1
]}

He, Yaqiang ^{[1
]}

Song, Chengjun ^{[1
]}

Dong, Zhijun ^{[2
]}

Su, Zhejun ^{[2
]}

Xue, Jingfeng ^{[1
]}

机构：

[1] Chengde Med Coll, Dept Human Anat, Chengde 067000, Hebei Province, Peoples R China

[2] Chengde Med Coll, Affiliated Hosp, Chengde 067000, Hebei Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 03期

关键词：

sericin; type 2 diabetes mellitus; hippocampus; apoptosis; Akt signal transduction pathway; neural regeneration; TRANSIENT CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; KAPPA-B; BAD TRANSLOCATION; SILK PROTEIN; SURVIVAL; MITOCHONDRIA; EXPRESSION; CORTEX; MOUSE;

D O I：

10.3969/j.issn.1673-5374.2012.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.

引用

页码：197 / 201

页数：5