Radiation-induced malformations after exposure of murine germ cells in various stages of spermatogenesis

被引：18

作者：

Müller, WU ^{[1
]}

Streffer, C ^{[1
]}

Wojcik, A ^{[1
]}

Niedereichholz, F ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Inst Med Strahlenbiol, D-45122 Essen, Germany

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1999年 / 425卷 / 01期

关键词：

paternal exposure; teratogenesis; gastroschisis; spermatogenesis; radiation risk;

D O I：

10.1016/S0027-5107(99)00028-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We studied radiation effects in day 19 fetuses of the mouse strain 'Heiligenberger' after exposure (2.8 Gy, 137 Cs gamma rays, dose rate 0.28 Gy/h) of their fathers. We observed an increased lethality (exclusively due to preimplantation death and early resorptions) after exposure of all stages of spermatogenesis with the exception of early spermatogonia. In addition, there was a significant increase in the frequency of malformed fetuses (gastroschises only); this increase was observed primarily after exposure of the meiotic stages. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：99 / 106

页数：8

共 25 条

[21]

SEARLE AG, 1974, MUTAT RES, V22, P63, DOI 10.1016/0165-1218(74)90052-4

[22] LEUKEMIA AND SELLAFIELD - IS THERE A HERITABLE LINK [J].

TAWN, EJ .

JOURNAL OF MEDICAL GENETICS, 1995, 32 (04) :251-256

[23] THE RISK OF CHILDHOOD-CANCER FROM INTRAUTERINE AND PRECONCEPTIONAL EXPOSURE TO IONIZING-RADIATION [J].

WAKEFORD, R .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 (11) :1018-1025

[24] METHODS AND CONCEPTS IN DETECTING ABNORMAL REPRODUCTIVE OUTCOMES OF PATERNAL ORIGIN [J].

WYROBEK, AJ .

REPRODUCTIVE TOXICOLOGY, 1993, 7 :3-16

[25] MORTALITY AND CANCER RISK AMONG THE OFFSPRING (F1) OF ATOMIC-BOMB SURVIVORS [J].

YOSHIMOTO, Y ;

MABUCHI, K .

JOURNAL OF RADIATION RESEARCH, 1991, 32 :294-300

← 1 2 3 →