Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N-Sulfonyl-1,2,3-triazoles

被引：26

作者：

Liu, Zhao ^{[1
]}

Du, Qiuchen ^{[1
]}

Zhai, Hongbin ^{[1
]}

Li, Yun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 23期

基金：

中国国家自然科学基金;

关键词：

DIVERGENT SYNTHESIS; SUBSTITUTED INDANONES; 3+2 CYCLOADDITION; ACCESS; 1-SULFONYL-1,2,3-TRIAZOLES; TRANSANNULATION; 1,2,3-TRIAZOLES; TRANSFORMATIONS; CONSTRUCTION; FRAMEWORK;

D O I：

10.1021/acs.orglett.8b03275

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereoselective synthesis of indolyl spiroindanones from readily accessible N-sulfony1-1,2,3-triazoles. This binary-catalyst system enables an aza-vinyl carbene initiated Pictet-Spengler-type cyclization and sequential cobaloxime promoted intramolecular Mannich-type reaction cascade. The easily accessible reagents, high diastereoselectivity, and operational simplicity make this reaction a method of choice for the preparation of functionalized spiroindanones, which are difficult to access by other classic reactions in one step.

引用

页码：7514 / 7517

页数：4

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