The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

被引：1034

作者：

Popoli, Maurizio ^{[2
,3
]}

Yan, Zhen ^{[4
]}

McEwen, Bruce S. ^{[5
]}

Sanacora, Gerard ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, Clin Neurosci Res Unit, New Haven, CT 06511 USA

[2] Univ Milan, Ctr Neuropharmacol, Dept Pharmacol Sci, I-20133 Milan, Italy

[3] Univ Milan, Ctr Excellence Neurodegenerat Dis, I-20133 Milan, Italy

[4] SUNY Buffalo, Sch Med & Biomed Sci, Dept Physiol & Biophys, Buffalo, NY 14214 USA

[5] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2012年 / 13卷 / 01期

关键词：

FIBRILLARY ACIDIC PROTEIN; EXTRASYNAPTIC NMDA RECEPTORS; LONG-TERM DEPRESSION; GAMMA-AMINOBUTYRIC-ACID; READILY RELEASABLE POOL; PREFRONTAL CORTEX; AMPA RECEPTOR; EXTRACELLULAR GLUTAMATE; MESSENGER-RNA; MINERALOCORTICOID RECEPTORS;

D O I：

10.1038/nrn3138

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mounting evidence suggests that acute and chronic stress, especially the stress-induced release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal cortex and the hippocampus, thereby influencing some aspects of cognitive processing. In addition, dysfunction of glutamatergic neurotransmission is increasingly considered to be a core feature of stress-related mental illnesses. Recent studies have shed light on the mechanisms by which stress and glucocorticoids affect glutamate transmission, including effects on glutamate release, glutamate receptors and glutamate clearance and metabolism. This new understanding provides insights into normal brain functioning, as well as the pathophysiology and potential new treatments of stress-related neuropsychiatric disorders.

引用

页码：22 / 37

页数：16

共 231 条

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