Developments Towards Regioselective Synthesis of 1,2-Disubstituted Benzimidazoles

被引：140

作者：

Carvalho, Luisa C. R. ^{[1
]}

Fernandes, Eduarda ^{[2
]}

Marques, M. Manuel B. ^{[1
]}

机构：

[1] Univ Nova Lisboa, Dept Quim, Fac Ciencias & Tecnol, P-2829516 Caparica, Portugal

[2] Univ Porto, Dept Ciencias Quim, Fac Farm, P-4099030 Oporto, Portugal

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 45期

关键词：

amination; cross-coupling; nitrogen heterocycles; regioselectivity; synthetic methods; ONE-POT SYNTHESIS; CATALYZED REGIOSPECIFIC SYNTHESIS; N BOND FORMATION; SELECTIVE SYNTHESIS; C-N; CASCADE REACTIONS; O-HALOANILINES; IONIC LIQUID; DERIVATIVES; EFFICIENT;

D O I：

10.1002/chem.201101508

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions.

引用

页码：12544 / 12555

页数：12

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