COVID-19 Vaccine Clinical Trials: A Bird's Eye Perspective

被引：0

作者：

Chennakesavulu, Pujitha Vallivedu ^{[1
]}

Cuddapah, Gaurav Venkat ^{[1
]}

Keesara, Mayura Reddy ^{[2
]}

Inampudi, Jyothik Varun ^{[3
]}

Arremsetty, Amulya ^{[3
]}

Moka, Sushma ^{[1
]}

Miryala, Swamy ^{[1
]}

机构：

[1] Kamineni Acad Med Sci & Res Ctr, Internal Med, Hyderabad, India

[2] Apollo Inst Med Sci & Res, Internal Med, Hyderabad, India

[3] Siddhartha Med Coll, Internal Med, Vijayawada, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 08期

关键词：

severe acute respiratory syndrome coronavirus-2 (sars-cov-2); sars-cov-2; covid-2019; infectious and tropical diseases; preventive health; covid; 19; clinical trials in all phases (i-iv); covid-19; vaccine;

D O I：

10.7759/cureus.28066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several Phase-III clinical studies investigating vaccine safety and effectiveness have been published a year following the first breakout of the COVID-19 pandemic. These vaccine candidates were produced using a variety of vaccination technologies, including mRNA, recombinant protein, adenoviral vector, and inactivated virus-based platforms, by various research organizations and pharmaceutical firms. Despite many successful clinical studies, participants are restricted by trial inclusion and exclusion criteria, geographic location, and the current state of the virus epidemic. Many concerns remain, particularly for specific populations such as the elderly, women who are pregnant or nursing, and teenagers. Vaccine effectiveness against asymptomatic infection and particular viral variations, on the other hand, is still largely unclear. This review will focus on vaccination candidates that have completed Phase-III clinical trials and will examine the scientific evidence that has been gathered so far for these vaccine candidates for various subgroups of individuals and virus variations.

引用

页数：7

共 35 条

[1]

Ajmera KM., 2022, Encyclopedia, V2, P457, DOI [10.3390/encyclopedia2010028, DOI 10.3390/ENCYCLOPEDIA2010028]

[2] Adverse Events following AstraZeneca COVID-19 Vaccine in Saudi Arabia: A Cross-Sectional Study among Healthcare and Nonhealthcare Workers [J].

Alghamdi, Ahlam A. ;

Alkazemi, Afrah ;

Alissa, Abdulrahman ;

Alghamdi, Isra ;

Alwarafi, Ghada ;

Waggas, Hadeel A. .

INTERVIROLOGY, 2022, 65 (02) :104-109

[3] Reactive arthritis after COVID-19 vaccination [J].

An, Qi-jun ;

Qin, De-an ;

Pei, Jin-xian .

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2021, 17 (09) :2954-2956

[4]

[Anonymous], 2021, EFFICACY SAFETY COVI

[5] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[6] Developing a vaccine for covid-19 Old and new strategies are being investigated in an unprecedented worldwide effort [J].

Caddy, Sarah .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 369

[7] Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population [J].

Ciabattini, Annalisa ;

Garagnani, Paolo ;

Santoro, Francesco ;

Rappuoli, Rino ;

Franceschi, Claudio ;

Medaglini, Donata .

SEMINARS IN IMMUNOPATHOLOGY, 2020, 42 (05) :619-634

[8] SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges [J].

Cooper, Dan M. ;

Afghani, Behnoush ;

Byington, Carrie L. ;

Cunningham, Coleen K. ;

Golub, Sidney ;

Lu, Kim D. ;

Radom-Aizik, Shlomit ;

Ross, Lainie Friedman ;

Singh, Jasjit ;

Smoyer, William E. ;

Lucas, Candice Taylor ;

Tunney, Jessica ;

Zaldivar, Frank ;

Ulloa, Erlinda R. .

PEDIATRIC RESEARCH, 2021, 90 (05) :966-970

[9] Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates [J].

Corbett, Kizzmekia S. ;

Flynn, Barbara ;

Foulds, Kathryn E. ;

Francica, Joseph R. ;

Boyoglu-Barnum, Seyhan ;

Werner, Anne P. ;

Flach, Britta ;

O'Connell, Sarah ;

Bock, Kevin W. ;

Minai, Mahnaz ;

Nagata, Bianca M. ;

Andersen, Hanne ;

Martinez, David R. ;

Noe, Amy T. ;

Douek, Naomi ;

Donaldson, Mitzi M. ;

Nji, Nadesh N. ;

Alvarado, Gabriela S. ;

Edwards, Darin K. ;

Flebbe, Dillon R. ;

Lamb, Evan ;

Doria-Rose, Nicole A. ;

Lin, Bob C. ;

Louder, Mark K. ;

O'Dell, Sijy ;

Schmidt, Stephen D. ;

Phung, Emily ;

Chang, Lauren A. ;

Yap, Christina ;

Todd, John-Paul M. ;

Pessaint, Laurent ;

Van Ry, Alex ;

Browne, Shanai ;

Greenhouse, Jack ;

Putman-Taylor, Tammy ;

Strasbaugh, Amanda ;

Campbell, Tracey-Ann ;

Cook, Anthony ;

Dodson, Alan ;

Steingrebe, Katelyn ;

Shi, Wei ;

Zhang, Yi ;

Abiona, Olubukola M. ;

Wang, Lingshu ;

Pegu, Amarendra ;

Yang, Eun Sung ;

Leung, Kwanyee ;

Zhou, Tongqing ;

Teng, I-Ting ;

Widge, Alicia .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) :1544-1555

[10] A rapid review of the impact of COVID-19 on the mental health of healthcare workers: implications for supporting psychological well-being [J].

De Kock, Johannes H. ;

Latham, Helen Ann ;

Leslie, Stephen J. ;

Grindle, Mark ;

Munoz, Sarah-Anne ;

Ellis, Liz ;

Polson, Rob ;

O'Malley, Christopher M. .

BMC PUBLIC HEALTH, 2021, 21 (01)

← 1 2 3 4 →