Obesity and male breast cancer: provocative parallels?

被引:26
作者
Humphries, Matthew P. [1 ]
Jordan, V. Craig [2 ]
Speirs, Valerie [1 ]
机构
[1] Univ Leeds, St Jamess Univ Hosp, Leeds Inst Canc & Pathol, Leeds LS9 7TF, W Yorkshire, England
[2] Univ Texas Houston, MD Anderson Canc Ctr, Dept Breast Med Oncol & Mol & Cellular Oncol, Houston, TX 77030 USA
来源
BMC MEDICINE | 2015年 / 13卷
关键词
Aromatase; Aromatase inhibitor; Body mass index; Estrogen; Incidence; Male breast cancer; Obesity; Risk factor; Selective estrogen receptor modulator; Tamoxifen; BODY-MASS INDEX; ADIPOSE-TISSUE; HYPOGONADOTROPIC HYPOGONADISM; GONADOTROPIN-SECRETION; AROMATASE INHIBITORS; POSTMENOPAUSAL WOMEN; SEX-HORMONES; RISK-FACTORS; MEN; ESTROGEN;
D O I
10.1186/s12916-015-0380-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
While rare compared to female breast cancer the incidence of male breast cancer (MBC) has increased in the last few decades. Without comprehensive epidemiological studies, the explanation for the increased incidence of MBC can only be speculated. Nevertheless, one of the most worrying global public health issues is the exponential rise in the number of overweight and obese people, especially in the developed world. Although obesity is not considered an established risk factor for MBC, studies have shown increased incidence among obese individuals. With this observation in mind, this article highlights the correlation between the increased incidence of MBC and the current trends in obesity as a growing problem in the 21st century, including how this may impact treatment. With MBC becoming more prominent we put forward the notion that, not only is obesity a risk factor for MBC, but that increasing obesity trends are a contributing factor to its increased incidence.
引用
收藏
页数:9
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