The interleukin-1 system and female reproduction

被引:139
作者
Gérard, N [1 ]
Caillaud, M [1 ]
Martoriati, A [1 ]
Goudet, G [1 ]
Lalmanach, AC [1 ]
机构
[1] INRA, UMR 6073, F-37380 Nouzilly, France
关键词
D O I
10.1677/joe.0.1800203
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interleukins (ILs) are known best for their involvement in the immune system and their role during inflammation. In the ovary, a growing body of evidence suggests that the ovarian follicle is a site of inflammatory reactions. Thus ovarian cells could represent sources and targets of ILs. Since then, the IL-1 system components (IL-1alpha, IL-1beta, IL-1 receptor antagonist, IL-1 receptors) have been demonstrated to have several sites of synthesis in the ovary. These factors have been localized in the various ovarian cell types, such as the oocyte, granulosa and theca cells, in several mammalian species. IL-1-like bioactivity has been reported in human and porcine follicular fluid at the time of ovulation. The role of IL-1 in local processes is still poorly known, although there is evidence for involvement in the ovulation process, and in oocyte maturation. More precisely, IL-1 may be involved in several ovulation-associated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production. IL-1 also regulates ovarian steroidogenesis. These different aspects of the involvement of the IL-1 system in important aspects of female reproduction are discussed.
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收藏
页码:203 / 212
页数:10
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