The synthesis of novel substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines without solvent under microwave irradiation

被引：40

作者：

Tu, SJ ^{[1
]}

Wei, QH

Ma, HJ

Shi, DQ

Gao, Y

Cui, GY

机构：

[1] Xuzhou Normal Univ, Dept Chem, Jiangsu 221009, Xuzhou, Peoples R China

[2] Normal Collegole Shenzhen Univ, Dept Chem, Shenzhen, Peoples R China

[3] Yangzhou Univ, Jiangsu Yangzhou 225001, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 17期

关键词：

Irradiation - X ray crystallography;

D O I：

10.1081/SCC-100105393

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthetic method for substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines is described. Heating Meldrum's acid, dimedone, ammonium acetate and different aromatic aldehydes without a solvent in a microwave irradiation for 2-5 minutes affords 4 in 72-86% yield. The structure of these compounds has been thoroughly studied by x-ray crystallographic analysis.

引用

页码：2657 / 2661

页数：5

共 8 条

[1] MICROWAVE-ASSISTED ORGANIC-REACTIONS [J].

CADDICK, S .

TETRAHEDRON, 1995, 51 (38) :10403-10432

[2]

CHRISTOPHER R, 1995, AUST J CHEM, V48, P1665

[3]

Feng JC, 1996, SYNTHETIC COMMUN, V26, P4545

[4] THE USE OF MICROWAVE-OVENS FOR RAPID ORGANIC-SYNTHESIS [J].

GEDYE, R ;

SMITH, F ;

WESTAWAY, K ;

ALI, H ;

BALDISERA, L ;

LABERGE, L ;

ROUSELL, J .

TETRAHEDRON LETTERS, 1986, 27 (03) :279-282

[5]

Janis R.A., 1987, Adv. Drug. Res, V16, P309

[6] NEW DEVELOPMENTS IN CA-2+ CHANNEL ANTAGONISTS [J].

JANIS, RA ;

TRIGGLE, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :775-785

[7]

Margarita S., 1999, TETRAHEDRON, V55, P875

[8] NOVEL DIHYDROPYRIDINES WITH POSITIVE INOTROPIC ACTION THROUGH ACTIVATION OF CA-2+ CHANNELS [J].

SCHRAMM, M ;

THOMAS, G ;

TOWART, R ;

FRANCKOWIAK, G .

NATURE, 1983, 303 (5917) :535-537

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