Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin

被引：84

作者：

Ando, H

Tsuruoka, S

Yanagihara, H

Sugimoto, K

Miyata, M

Yamazoe, Y

Takamura, T

Kaneko, S

Fujimura, A ^{[1
]}

机构：

[1] Jichi Med Sch, Dept Pharmacol, Div Clin Pharmacol, Tochigi 3290498, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Div Drug Metab & Mol Toxicol, Sendai, Miyagi 980, Japan

[3] Kanazawa Univ, Grad Sch Med Sci, Dept Diabet & Digest Dis, Kanazawa, Ishikawa 920, Japan

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2005年 / 60卷 / 05期

关键词：

pitavastatin; atorvastatin; HMG-CoA reductase inhibitors; grapefruit juice; CYP3A4; drug interaction;

D O I：

10.1111/j.1365-2125.2005.02462.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims To compare the effects of grapefruit juice (GFJ) on the pharmacokinetics of pitavastatin and atorvastatin. Methods In a randomized, four-phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On each final day, a single dose of 4 mg pitavastatin or 20 mg atorvastatin was administered. Results GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin acid by 13% (-3 to 29%). Conclusions Pitavastatin, unlike atorvastatin, appears to be scarcely affected by the CYP3A4-mediated metabolism.

引用

页码：494 / 497

页数：4

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