Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin

被引：85
作者：
Ando, H
Tsuruoka, S
Yanagihara, H
Sugimoto, K
Miyata, M
Yamazoe, Y
Takamura, T
Kaneko, S
Fujimura, A [1 ]
机构：
[1] Jichi Med Sch, Dept Pharmacol, Div Clin Pharmacol, Tochigi 3290498, Japan
[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Div Drug Metab & Mol Toxicol, Sendai, Miyagi 980, Japan
[3] Kanazawa Univ, Grad Sch Med Sci, Dept Diabet & Digest Dis, Kanazawa, Ishikawa 920, Japan
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2005年 / 60卷 / 05期
关键词：
pitavastatin; atorvastatin; HMG-CoA reductase inhibitors; grapefruit juice; CYP3A4; drug interaction;
D O I：
10.1111/j.1365-2125.2005.02462.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aims To compare the effects of grapefruit juice (GFJ) on the pharmacokinetics of pitavastatin and atorvastatin. Methods In a randomized, four-phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On each final day, a single dose of 4 mg pitavastatin or 20 mg atorvastatin was administered. Results GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin acid by 13% (-3 to 29%). Conclusions Pitavastatin, unlike atorvastatin, appears to be scarcely affected by the CYP3A4-mediated metabolism.
引用
收藏
页码：494 / 497
页数：4
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