Photodynamic therapy for early-stage cervical cancer treatment

Background: The aim of this article is a retrospective analysis of PDT effectiveness in the treatment in early-stage cervical cancer and also analysis of HPV elimination via PDT Material and methods: A total of 28 patients were analyzed retrospectively, all with PDT treatment for early-stage cervical cancer. Patients underwent one PDT session or a multi-course PDT approach. This depended on individual reaction and response to therapy after the first session. A multi-course approach was performed over two months. Treatments were performed from 2015 to 2020. Relapse-free probability was assessed for these patients by Kaplan Meier estimator at 60 months and HPV elimiantion was also examined.. Results: HPV elimination was in 82% of cases in three-month period after PDT (R-2 = 0.71). Among the analyzed cases, full HPV elimination was detected in more than 90% of cases. Relapse-free probability from cervical cancer is 0,8 (CI95%: 0,53-1) at 60 months. Patients had mild (35.7%) and severe (28.6%) leucocyte reactions after PDT in three months. Conclusion: The article demonstrates treatment results for CC and detected a five-year period relapse-free probability after PDT. Patients completing a multi-treatment PDT protocol for invasive cervical cancer can achieve both high response rate and relapse-free survival.