Scop3D: Online Visualization of Mutation Rates on Protein Structure

被引：1

作者：

Kreft, Lukasz ^{[1
]}

Turan, Demet ^{[2
,3
]}

Hulstaert, Niels ^{[2
,3
]}

Botzki, Alexander ^{[1
]}

Martens, Lennart ^{[2
,3
]}

Vandermarliere, Elien ^{[2
,3
,4
]}

机构：

[1] VIB, VIB Bioinformat Core, B-9052 Ghent 120, Belgium

[2] VIB, VIB UGent Ctr Med Biotechnol, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

[4] VIB, VIB Headquarters, B-1209052 Ghent, Belgium

来源：

JOURNAL OF PROTEOME RESEARCH | 2019年 / 18卷 / 02期

关键词：

Scop3D; protein sequence; DNA sequence; protein structure; conservation; SEQUENCE; PATHWAY;

D O I：

10.1021/acs.jproteome.8b00681

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Scop3D is a tool that automatically annotates protein structure with sequence conservation starting from a set of protein sequence variants. We present a complete upgrade and rewrite of Scop3D. We have included a DNA module that allows the analysis of single nucleotide polymorphisms in relation to the structural context of the protein. Scop3D therefore forms a bridge between genomics and protein structure. Moreover, Scop3D is now also available through an intuitive web-interface that makes the tool highly user-friendly.

引用

页码：765 / 769

页数：5

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