Novel ferrocene-based inhibitor of proteins glycation

被引：4

作者：

Milaeva, E. R. ^{[1
,2
]}

Shpakovsky, D. B. ^{[1
]}

Meleshonkova, N. N. ^{[1
]}

Orlova, S. I. ^{[1
]}

Shevtsova, E. F. ^{[2
]}

Dubova, L. G. ^{[2
]}

Kireeva, E. G. ^{[2
]}

Kosolapov, V. A. ^{[3
]}

Kusnetsova, V. A. ^{[3
]}

Sorotsky, D. V. ^{[3
]}

Solov'eva, O. A. ^{[3
]}

Spasov, A. A. ^{[3
]}

机构：

[1] Moscow MV Lomonosov State Univ, 1 Bldg 3 Leninskie Gory, Moscow 119991, Russia

[2] Russian Acad Sci, Inst Physiocologically Act Cpds, Chernogolovka 142432, Moscow Region, Russia

[3] Volgograd State Univ, Volgograd 400131, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

2,6-di-tert-butylphenol; ferrocene; lipid peroxidation; antioxidant activity; protein glycation; MAILLARD REACTION; END-PRODUCTS; ANTIOXIDANT ACTIVITY; COMPLICATIONS; MECHANISMS; OXIDATION; DISEASES; SYSTEM;

D O I：

10.1007/s11172-015-1138-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antioxidant and antiglycating activities of 2,6-di-tert-butyl-4-[N-(4-pyridyl) imino-methyl] phenol (1), 2,6-di-tert-butyl-4-[N-(3-pyridylmethyl)-iminomethyl] phenol (2) and N-(3,5-di-tert-butyl-4-hydroxyphenyl)iminomethylferrocene (3) have been studied. Antioxidant activity of 2,6-di-tert-butylphenol bearing ferrocenyl moiety was shown to be sufficiently higher than that of the compounds 1 and 2. Based on the data obtained in comparison with aminoguanidine which is an effective protein glycation inhibitor it was established that the introduction of ferrocenyl moiety into 2,6-di-tert-butylphenol results in a dramatic increase in the antiglycating activity exceeding that for aminoguanidine.

引用

页码：2195 / 2202

页数：8

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