Diallyl Trisulfide attenuates alcohol-induced hepatocyte pyroptosis via elevation of hydrogen sulfide

被引：8
作者：
Zhu, Xiaojing [1 ]
Lu, Rongxin [2 ,3 ]
Zhang, Genrong [1 ]
Fan, Lin [1 ]
Zhan, Yongjiu [4 ]
Chen, Guoxin [1 ]
Zhou, Liang [2 ,3 ]
机构：
[1] Suzhou Hosp Integrated Tradit Chinese & Western M, Dept Pharm, Suzhou, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Suzhou TCM Hosp, Clin Pharmaceut Lab Tradit Chinese Med, Suzhou, Jiangsu, Peoples R China
[3] Suzhou Acad Wumen Chinese Med, Clin Pharmaceut Lab Tradit Chinese Med, Suzhou, Jiangsu, Peoples R China
[4] Suzhou Hosp Integrated Tradit Chinese & Western M, Dept Dermatologists, Suzhou, Jiangsu, Peoples R China
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2022年 / 86卷 / 11期
基金：
中国国家自然科学基金;
关键词：
diallyl trisulfide; alcoholic liver disease; hepatocyte; pyroptosis; hydrogen sulfide; NF-KAPPA-B; OXIDATIVE STRESS; HEPATIC STEATOSIS; LIVER-INJURY; ACTIVATION; APOPTOSIS; MICE; DYSFUNCTION; PROTECTS; CLEAVAGE;
D O I：
10.1093/bbb/zbac149
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Garlic is a popular culinary herb for the prevention and treatment of alcoholic liver disease (ALD). Diallyl Trisulfide (DATS) is the major organosulfur compound of garlic. Latest studies indicated that the hepatocyte pyroptosis serves a primary role in the pathogenesis of ALD. The present study aims to assess the inhibitory effect of DATS on alcohol-induced hepatocyte pyroptosis, and to elucidate the potential mechanism by using the hepatocyte cell line HL-7702. Our study found that DATS inhibited alcohol-induced pyroptosis by decreasing gasdermin D (GSDMD) activation. Results illuminated that DATS inhibited alcohol-induced (NOD)-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation by reducing intracellular reactive oxygen species (ROS) accumulation. Furthermore, DATS upregulated hydrogen sulfide (H2S) to resist ROS overproduction. The present study demonstrated that DATS mitigated alcohol-induced hepatocyte pyroptosis by increasing the intracellular level of H2S.
引用
收藏
页码：1552 / 1561
页数：10
相关论文
共 50 条
  • [1] Amagase H., 2001, Journal of Nutrition, V131, P955
  • [2] Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review
    Ariga, Toyohiko
    Seki, Taiichiro
    [J]. BIOFACTORS, 2006, 26 (02) : 93 - 103
  • [3] Nrf2-Keap1 signaling in oxidative and reductive stress
    Bellezza, Ilaria
    Giambanco, Ileana
    Minelli, Alba
    Donato, Rosario
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2018, 1865 (05): : 721 - 733
  • [4] Chang Thomas K H, 2006, Methods Mol Biol, V320, P127
  • [5] Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism
    Chen, Lian-Yun
    Chen, Qin
    Zhu, Xiao-Jing
    Kong, De-Song
    Wu, Li
    Shao, Jiang-juan
    Zheng, Shi-Zhong
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 36 : 23 - 30
  • [6] Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis
    Chen, Lian-Yun
    Chen, Qin
    Cheng, Feng
    Jin, Huan-Huan
    Kong, De-Song
    Zhang, Feng
    Wu, Li
    Shao, Jiang-juan
    Zheng, Shi-Zhong
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2016, 79 : 35 - 43
  • [7] Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis
    Dai, Weibo
    Chen, Chang
    Feng, Huiting
    Li, Guangru
    Peng, Weiwen
    Liu, Xin
    Yang, Jing
    Hu, Xianjing
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2021, 275
  • [8] Caffeic acid phenethyl ester against cadmium induced toxicity mediated by CircRNA modulates autophagy in HepG2 cells
    Hao, Rili
    Li, Feng
    Song, Xinyu
    Tan, Xintong
    Sun-Waterhouse, Dongxiao
    Li, Dapeng
    [J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 197
  • [9] Mechanism and Regulation of NLRP3 Inflammasome Activation
    He, Yuan
    Hara, Hideki
    Nunez, Gabriel
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2016, 41 (12) : 1012 - 1021
  • [10] Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression
    Heo, Mi Jeong
    Kim, Tae Hyun
    You, Jueng Soo
    Blaya, Delia
    Sancho-Bru, Pau
    Kim, Sang Geon
    [J]. GUT, 2019, 68 (04) : 708 - 720
12345