Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses

被引:85
作者
Sievers, Benjamin L. [1 ]
Chakraborty, Saborni [2 ]
Xue, Yong [3 ]
Gelbart, Terri [1 ]
Gonzalez, Joseph C. [2 ,4 ]
Cassidy, Arianna G. [5 ]
Golan, Yarden [6 ,7 ]
Prahl, Mary [8 ]
Gaw, Stephanie L. [5 ]
Arunachalam, Prabhu S. [9 ]
Blish, Catherine A. [2 ,4 ,10 ]
Boyd, Scott D. [11 ,12 ,13 ]
Davis, Mark M. [9 ,12 ,14 ]
Jagannathan, Prasanna [2 ,12 ]
Nadeau, Kari C. [13 ]
Pulendran, Bali [9 ]
Singh, Upinder [2 ,12 ]
Scheuermann, Richard H. [1 ,15 ]
Frieman, Matthew B. [16 ]
Vashee, Sanjay [3 ]
Wang, Taia T. [2 ,4 ,10 ,12 ]
Tan, Gene S. [1 ,17 ]
机构
[1] J Craig Venter Inst, La Jolla, CA 92037 USA
[2] Stanford Univ, Dept Med, Div Infect Dis, Stanford, CA 94305 USA
[3] J Craig Venter Inst, Rockville, MD 20850 USA
[4] Stanford Univ, Program Immunol, Sch Med, Stanford, CA 94305 USA
[5] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Div Maternal Fetal Med, San Francisco, CA 94115 USA
[6] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94115 USA
[7] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94115 USA
[8] Univ Calif San Francisco, Dept Pediat, Div Pediat Infect Dis, San Francisco, CA 94115 USA
[9] Stanford Univ, Inst Immun Transplantat & Infect, Sch Med, Stanford, CA 94305 USA
[10] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA
[11] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[12] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[13] Sean N Parker Ctr Allergy & Asthma Res, Dept Med, Stanford, CA 94305 USA
[14] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA
[15] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92037 USA
[16] Univ Maryland, Ctr Pathogen Res, Dept Microbiol & Immunol, Sch Med, Baltimore, MD 21201 USA
[17] Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92037 USA
关键词
D O I
10.1126/scitranslmed.abn7842
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the current vaccines have largely been effective against past variants, the number of mutations found on the Omicron (B.1.1.529) spike protein appear to diminish the protection conferred by preexisting immunity. Using vesicular stomatitis virus (VSV) pseudoparticles expressing the spike protein of several SARS-CoV-2 variants, we evaluated the magnitude and breadth of the neutralizing antibody response over time in individuals after infection and in mRNA-vaccinated individuals. We observed that boosting increases the magnitude of the antibody response to wild-type (D614), Beta, Delta, and Omicron variants; however, the Omicron variant was the most resistant to neutralization. We further observed that vaccinated healthy adults had robust and broad antibody responses, whereas responses may have been reduced in vaccinated pregnant women, underscoring the importance of learning how to maximize mRNA vaccine responses in pregnant populations. Findings from this study show substantial heterogeneity in the magnitude and breadth of responses after infection and mRNA vaccination and may support the addition of more conserved viral antigens to existing SARS-CoV-2 vaccines.
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页数:8
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