Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses

被引:82
作者
Sievers, Benjamin L. [1 ]
Chakraborty, Saborni [2 ]
Xue, Yong [3 ]
Gelbart, Terri [1 ]
Gonzalez, Joseph C. [2 ,4 ]
Cassidy, Arianna G. [5 ]
Golan, Yarden [6 ,7 ]
Prahl, Mary [8 ]
Gaw, Stephanie L. [5 ]
Arunachalam, Prabhu S. [9 ]
Blish, Catherine A. [2 ,4 ,10 ]
Boyd, Scott D. [11 ,12 ,13 ]
Davis, Mark M. [9 ,12 ,14 ]
Jagannathan, Prasanna [2 ,12 ]
Nadeau, Kari C. [13 ]
Pulendran, Bali [9 ]
Singh, Upinder [2 ,12 ]
Scheuermann, Richard H. [1 ,15 ]
Frieman, Matthew B. [16 ]
Vashee, Sanjay [3 ]
Wang, Taia T. [2 ,4 ,10 ,12 ]
Tan, Gene S. [1 ,17 ]
机构
[1] J Craig Venter Inst, La Jolla, CA 92037 USA
[2] Stanford Univ, Dept Med, Div Infect Dis, Stanford, CA 94305 USA
[3] J Craig Venter Inst, Rockville, MD 20850 USA
[4] Stanford Univ, Program Immunol, Sch Med, Stanford, CA 94305 USA
[5] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Div Maternal Fetal Med, San Francisco, CA 94115 USA
[6] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94115 USA
[7] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94115 USA
[8] Univ Calif San Francisco, Dept Pediat, Div Pediat Infect Dis, San Francisco, CA 94115 USA
[9] Stanford Univ, Inst Immun Transplantat & Infect, Sch Med, Stanford, CA 94305 USA
[10] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA
[11] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[12] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[13] Sean N Parker Ctr Allergy & Asthma Res, Dept Med, Stanford, CA 94305 USA
[14] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA
[15] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92037 USA
[16] Univ Maryland, Ctr Pathogen Res, Dept Microbiol & Immunol, Sch Med, Baltimore, MD 21201 USA
[17] Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92037 USA
关键词
D O I
10.1126/scitranslmed.abn7842
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the current vaccines have largely been effective against past variants, the number of mutations found on the Omicron (B.1.1.529) spike protein appear to diminish the protection conferred by preexisting immunity. Using vesicular stomatitis virus (VSV) pseudoparticles expressing the spike protein of several SARS-CoV-2 variants, we evaluated the magnitude and breadth of the neutralizing antibody response over time in individuals after infection and in mRNA-vaccinated individuals. We observed that boosting increases the magnitude of the antibody response to wild-type (D614), Beta, Delta, and Omicron variants; however, the Omicron variant was the most resistant to neutralization. We further observed that vaccinated healthy adults had robust and broad antibody responses, whereas responses may have been reduced in vaccinated pregnant women, underscoring the importance of learning how to maximize mRNA vaccine responses in pregnant populations. Findings from this study show substantial heterogeneity in the magnitude and breadth of responses after infection and mRNA vaccination and may support the addition of more conserved viral antigens to existing SARS-CoV-2 vaccines.
引用
收藏
页数:8
相关论文
共 29 条
  • [1] Systems vaccinology of the BNT162b2 mRNA vaccine in humans
    Arunachalam, Prabhu S.
    Scott, Madeleine K. D.
    Hagan, Thomas
    Li, Chunfeng
    Feng, Yupeng
    Wimmers, Florian
    Grigoryan, Lilit
    Trisal, Meera
    Edara, Venkata Viswanadh
    Lai, Lilin
    Chang, Sarah Esther
    Feng, Allan
    Dhingra, Shaurya
    Shah, Mihir
    Lee, Alexandra S.
    Chinthrajah, Sharon
    Sindher, Sayantani B.
    Mallajosyula, Vamsee
    Gao, Fei
    Sigal, Natalia
    Kowli, Sangeeta
    Gupta, Sheena
    Pellegrini, Kathryn
    Tharp, Gregory
    Maysel-Auslender, Sofia
    Hamilton, Sydney
    Aoued, Hadj
    Hrusovsky, Kevin
    Roskey, Mark
    Bosinger, Steven E.
    Maecker, Holden T.
    Boyd, Scott D.
    Davis, Mark M.
    Utz, Paul J.
    Suthar, Mehul S.
    Khatri, Purvesh
    Nadeau, Kari C.
    Pulendran, Bali
    [J]. NATURE, 2021, 596 (7872) : 410 - +
  • [2] CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
    Bange, Erin M.
    Han, Nicholas A.
    Wileyto, Paul
    Kim, Justin Y.
    Gouma, Sigrid
    Robinson, James
    Greenplate, Allison R.
    Hwee, Madeline A.
    Porterfield, Florence
    Owoyemi, Olutosin
    Naik, Karan
    Zheng, Cathy
    Galantino, Michael
    Weisman, Ariel R.
    Ittner, Caroline A. G.
    Kugler, Emily M.
    Baxter, Amy E.
    Oniyide, Olutwatosin
    Agyekum, Roseline S.
    Dunn, Thomas G.
    Jones, Tiffanie K.
    Giannini, Heather M.
    Weirick, Madison E.
    McAllister, Christopher M.
    Babady, N. Esther
    Kumar, Anita
    Widman, Adam J.
    DeWolf, Susan
    Boutemine, Sawsan R.
    Roberts, Charlotte
    Budzik, Krista R.
    Tollett, Susan
    Wright, Carla
    Perloff, Tara
    Sun, Lova
    Mathew, Divij
    Giles, Josephine R.
    Oldridge, Derek A.
    Wu, Jennifer E.
    Alanio, Cecile
    Adamski, Sharon
    Garfall, Alfred L.
    Vella, Laura A.
    Kerr, Samuel J.
    Cohen, Justine, V
    Oyer, Randall A.
    Massa, Ryan
    Maillard, Ivan P.
    Maxwell, Kara N.
    Reilly, John P.
    [J]. NATURE MEDICINE, 2021, 27 (07) : 1280 - +
  • [3] The use of pseudotypes to study viruses, virus sero-epidemiology and vaccination
    Bentley, Emma M.
    Mather, Stuart T.
    Temperton, Nigel J.
    [J]. VACCINE, 2015, 33 (26) : 2955 - 2962
  • [4] Cameroni E, 2022, NATURE, V602, P664, DOI [10.1038/s41586-021-04386-2, 10.1101/2021.12.12.472269]
  • [5] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
    Cele, Sandile
    Jackson, Laurelle
    Khoury, David S.
    Khan, Khadija
    Moyo-Gwete, Thandeka
    Tegally, Houriiyah
    San, James Emmanuel
    Cromer, Deborah
    Scheepers, Cathrine
    Amoako, Daniel G.
    Karim, Farina
    Bernstein, Mallory
    Lustig, Gila
    Archary, Derseree
    Smith, Muneerah
    Ganga, Yashica
    Jule, Zesuliwe
    Reedoy, Kajal
    Hwa, Shi-Hsia
    Giandhari, Jennifer
    Blackburn, Jonathan M.
    Gosnell, Bernadett, I
    Karim, Salim S. Abdool
    Hanekom, Willem
    von Gottberg, Anne
    Bhiman, Jinal N.
    Lessells, Richard J.
    Moosa, Mahomed-Yunus S.
    Davenport, Miles P.
    de Oliveira, Tulio
    Moore, Penny L.
    Sigal, Alex
    [J]. NATURE, 2022, 602 (7898) : 654 - +
  • [6] Chakraborty Saborni, 2021, bioRxiv, DOI 10.1101/2021.05.25.445649
  • [7] SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?
    Chakraborty, Saborni
    Mallajosyula, Vamsee
    Tato, Cristina M.
    Tan, Gene S.
    Wang, Taia T.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2021, 172 : 314 - 338
  • [8] Chakraborty S, 2021, NAT IMMUNOL, V22, P67, DOI [10.1038/s41590-020-00828-7, 10.1101/2020.05.15.20103341]
  • [9] Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women
    Collier, Ai-ris Y.
    McMahan, Katherine
    Yu, Jingyou
    Tostanoski, Lisa H.
    Aguayo, Ricardo
    Ansel, Jessica
    Chandrashekar, Abishek
    Patel, Shivani
    Apraku Bondzie, Esther
    Sellers, Daniel
    Barrett, Julia
    Sanborn, Owen
    Wan, Huahua
    Chang, Aiquan
    Anioke, Tochi
    Nkolola, Joseph
    Bradshaw, Connor
    Jacob-Dolan, Catherine
    Feldman, Jared
    Gebre, Makda
    Borducchi, Erica N.
    Liu, Jinyan
    Schmidt, Aaron G.
    Suscovich, Todd
    Linde, Caitlyn
    Alter, Galit
    Hacker, Michele R.
    Barouch, Dan H.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (23): : 2370 - 2380
  • [10] Doria-Rose Nicole A, 2021, medRxiv, DOI 10.1101/2021.12.15.21267805