Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

被引：138
作者：
Liaras, K. [1 ]
Geronikaki, A. [1 ]
Glamoclija, J. [2 ]
Ciric, A. [2 ]
Sokovic, M. [2 ]
机构：
[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece
[2] Univ Belgrade, Mycol Lab, Inst Biol Res S Stankovic, Belgrade, Serbia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 10期
关键词：
Thiazole; Chalcones; Antibacterial; Antifungal; DERIVATIVES; ANTIFUNGAL; DESIGN; ANTIBACTERIAL;
D O I：
10.1016/j.bmc.2011.04.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties. Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3135 / 3140
页数：6
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