Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction

被引：48
作者：
Yu, Bin [1 ,2 ]
Fang, Tai-Hui [1 ]
Lue, Gao-Hong [2 ]
Xu, Hui-Qin [2 ]
Lu, Jin-Fu [2 ]
机构：
[1] Nanjing Univ Tradit Chinese Med, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Univ Tradit Chinese Med, Prov & Minist Cooperat Lab Pharmacol Chinese Med, Nanjing, Jiangsu, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 06期
关键词：
Cyclovirobuxine D; Heart failure; Cardiac function; Myocardial infarction; DILATED CARDIOMYOPATHY; IMPROVES; MICROCIRCULATION; DYSFUNCTION; EXTRACT; MODEL;
D O I：
10.1016/j.fitote.2011.04.016
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered for 30 days (0.5, 1.0 and 2.0 mg/kg, ig) and mortality, cardiac function, hemodynamics, microcirculation, histology and ultrastructure assessments were observed. Results from the present study suggest that Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction and supports the potential for Cyclovirobuxine D as a new therapy for heart failure. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：868 / 877
页数：10
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