Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification

被引：22
作者：
Yang, Qingfan [1 ,2 ]
Chen, Yu [2 ,3 ,4 ]
Guo, Rui [1 ]
Dai, Yalan [1 ,2 ]
Tang, Liyao [3 ,4 ]
Zhao, Yueshui [2 ,3 ,4 ]
Wu, Xu [2 ,3 ,4 ]
Li, Mingxing [2 ,3 ,4 ]
Du, Fukuan [2 ,3 ,4 ]
Shen, Jing [2 ,3 ,4 ]
Yi, Tao [5 ]
Xiao, Zhangang [2 ,3 ,4 ]
Wen, Qinglian [1 ,2 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China
[2] South Sichuan Inst Translat Med, Luzhou, Peoples R China
[3] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Peoples R China
[4] Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou, Peoples R China
[5] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 11卷
基金：
中国国家自然科学基金;
关键词：
ncRNA; histone modification; gastric cancer; epigenetic modifications; mechanisms; LONG NONCODING RNA; INHIBITS CELL-PROLIFERATION; POSTTRANSLATIONAL MODIFICATION; CYCLE PROGRESSION; PHOSPHORYLATION; H3; INVASION; CARCINOGENESIS; TRANSCRIPTION; SUMOYLATION;
D O I：
10.3389/fonc.2021.822745
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.
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页数：17
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