Ligand-stabilized hairpin structures interfere with elongation of human telomere

被引：8
作者：
Hagihara, Masaki [1 ,2 ]
Goto, Yuki [2 ]
Nakatani, Kazuhiko [1 ,2 ]
机构：
[1] Osaka Univ, Dept Regulatory Bioorgan Chem, Inst Sci & Ind Res, Ibaraki 5670047, Japan
[2] Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Kyoto 6158510, Japan
来源：
CHEMBIOCHEM | 2008年 / 9卷 / 04期
关键词：
DNA recognition; DNA structures; hairpins inhibitors; telomeric overhangs;
D O I：
10.1002/cbic.200700667
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：510 / 513
页数：4
相关论文
共 19 条
  • [1] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    Ambrus, Attila
    Chen, Ding
    Dai, Jixun
    Bialis, Tiffanie
    Jones, Roger A.
    Yang, Danzhou
    [J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (09) : 2723 - 2735
  • [2] BALAGURUMOORTHY P, 1994, J BIOL CHEM, V269, P21858
  • [3] Small-molecule binding to the nonquadruplex form of the human telomeric sequence
    Goto, Yuki
    Hagihara, Shinya
    Hagihara, Masaki
    Nakatani, Kazuhiko
    [J]. CHEMBIOCHEM, 2007, 8 (07) : 723 - 726
  • [4] Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
    Gowan, SM
    Heald, R
    Stevens, MFG
    Kelland, LR
    [J]. MOLECULAR PHARMACOLOGY, 2001, 60 (05) : 981 - 988
  • [5] A DNA polymerase stop assay for G-quadruplex-interactive compounds
    Han, HY
    Hurley, LH
    Salazar, M
    [J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (02) : 537 - 542
  • [6] DNA and its associated processes as targets for cancer therapy
    Hurley, LH
    [J]. NATURE REVIEWS CANCER, 2002, 2 (03) : 188 - 200
  • [7] Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics - current status and future prospects
    Kelland, LR
    [J]. EUROPEAN JOURNAL OF CANCER, 2005, 41 (07) : 971 - 979
  • [8] Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
    Koeppel, F
    Riou, JF
    Laoui, A
    Mailliet, P
    Arimondo, PB
    Labit, D
    Petitgenet, O
    Hélène, C
    Mergny, JL
    [J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (05) : 1087 - 1096
  • [9] Structure of the human telomere in K+ solution:: An intramolecular (3+1) G-quadruplex scaffold
    Luu, Kim Ngoc
    Phan, Anh Tuan
    Kuryavyi, Vitaly
    Lacroix, Laurent
    Patel, Dinshaw J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (30) : 9963 - 9970
  • [10] Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    Makarov, VL
    Hirose, Y
    Langmore, JP
    [J]. CELL, 1997, 88 (05) : 657 - 666
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