Micromolding for ceramic microneedle arrays

被引：107
作者：
Bystrova, S. [1 ]
Luttge, R. [1 ]
机构：
[1] Univ Twente, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands
来源：
MICROELECTRONIC ENGINEERING | 2011年 / 88卷 / 08期
关键词：
Microneedles; Micromolding; Ceramic; Porous; Drug delivery;
D O I：
10.1016/j.mee.2010.12.067
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The fabrication process of ceramic microneedle arrays (MNAs) is presented. This includes the manufacturing of an SU-8/Si-master, its double replication resulting in a PDMS mold for production by micromolding and ceramic sintering. The robustness of the replicated structures was tested by means of microindentation techniques eliminating shear forces and by manual application of MNAs into silicone rubber. No damages of MNAs were observed using controlled microindentation. After the manual application, however, some microneedles were broken and left in the silicone. The opportunities and the ways to solve underlying problems of the fabrication process will be suggested and discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1681 / 1684
页数：4
相关论文
共 8 条
  • [1] Process mechanism for vacuum-assisted microfluidic lithography with ceramic colloidal suspensions
    Ahn, Sung-Jin
    Min, Ji-Hyun
    Kim, Joosun
    Moon, Jooho
    [J]. JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2008, 91 (07) : 2143 - 2149
  • [2] Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin
    Chen, Xianfeng
    Prow, Tarl W.
    Crichton, Michael L.
    Jenkins, Derek W. K.
    Roberts, Michael S.
    Frazer, Ian H.
    Fernando, Germain J. P.
    Kendall, Mark A. F.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2009, 139 (03) : 212 - 220
  • [3] Silicon micromachined hollow microneedles for transdermal liquid transport
    Gardeniers, HJGE
    Luttge, R
    Berenschot, EJW
    de Boer, MJ
    Yeshurun, SY
    Hefetz, M
    van't Oever, R
    van den Berg, A
    [J]. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2003, 12 (06) : 855 - 862
  • [4] Mechanical strength and interfacial failure analysis of cantilevered SU-8 microposts
    Khoo, HS
    Liu, KK
    Tseng, FG
    [J]. JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2003, 13 (06) : 822 - 831
  • [5] Kwon S.-Y., 2004, Patent, Patent No. [2004/024224, 2004024224]
  • [6] Park G.H., 2006, PHARM RES, V23, P1008
  • [7] Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method
    Verbaan, F. J.
    Bal, S. M.
    van den Berg, D. J.
    Dijksman, J. A.
    van Hecke, M.
    Verpoorten, H.
    van den Berg, A.
    Luttge, R.
    Bouwstra, J. A.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2008, 128 (01) : 80 - 88
  • [8] A soft moulding process for manufacture of net-shape ceramic microcomponents
    Zhu, Zhigang
    Hassanin, Hany
    Jiang, Kyle
    [J]. INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2010, 47 (1-4) : 147 - 152
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