Association of COVID-19 with New-Onset Alzheimer's Disease

被引：102

作者：

Wang, Lindsey ^{[1
]}

Davis, Pamela B. ^{[2
]}

Volkow, Nora D. ^{[3
]}

Berger, Nathan A. ^{[1
]}

Kaelber, David C. ^{[4
]}

Xu, Rong ^{[5
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Ctr Sci Hlth & Soc, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Ctr Community Hlth Integrat, Cleveland, OH 44106 USA

[3] NIDA, NIH, Bethesda, MD 20892 USA

[4] Metro Hlth Syst, Ctr Clin Informat Res & Educ, Cleveland, OH USA

[5] Case Western Reserve Univ, Sch Med, Ctr Artificial Intelligence Drug Discovery, Cleveland, OH 44106 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 89卷 / 02期

关键词：

Alzheimer's disease; COVID-19; electronic health records; viral etiology;

D O I：

10.3233/JAD-220717

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An infectious etiology of Alzheimer's disease has been postulated for decades. It remains unknown whether SARSCoV-2 viral infection is associated with increased risk for Alzheimer's disease. In this retrospective cohort study of 6,245,282 older adults (age >= 65 years) who had medical encounters between 2/2020-5/2021, we show that people with COVID-19 were at significantly increased risk for new diagnosis of Alzheimer's disease within 360 days after the initial COVID-19 diagnosis (hazard ratio or HR:1.69, 95% CI: 1.53-1.72), especially in people age >= 85 years and in women. Our findings call for research to understand the underlying mechanisms and for continuous surveillance of long-term impacts of COVID-19 on Alzheimer's disease.

引用

页码：411 / 414

页数：4

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