What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

被引：140
作者：
Davis, Ian [1 ,2 ]
Liu, Aimin [1 ,2 ,3 ]
机构：
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
[2] Georgia State Univ, Mol Basis Dis Program, Atlanta, GA 30303 USA
[3] Ctr Diagnost & Therapeut, Atlanta, GA 30303 USA
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 07期
关键词：
excitotoxicity; inflammation; melatonin; quinolinic acid; serotonin; BRAIN; DECARBOXYLASE; DIOXYGENASES; METABOLITES; DEPRESSION; DISCOVERY; DISORDERS; OXIDATION; TARGETS;
D O I：
10.1586/14737175.2015.1049999
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The kynurenine pathway has received increasing attention as its connection to inflammation, the immune system and neurological conditions has become more apparent. It is the primary route for tryptophan catabolism in the liver and the starting point for the synthesis of nicotinamide adenine dinucleotide in mammals. Dysregulation or overactivation of this pathway can lead to immune system activation and accumulation of potentially neurotoxic compounds. These aspects make the kynurenine pathway a promising target for therapeutic development to treat inflammation and disease with neurological aspects, especially in cancer patients undergoing chemotherapy.
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收藏
页码：719 / 721
页数：3
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