The role of bypass filters in deceased donor kidney allocation in the United States

被引:15
作者
King, Kristen L. [1 ,2 ]
Husain, S. Ali [1 ,2 ]
Cohen, David J. [1 ]
Schold, Jesse D. [3 ,4 ]
Mohan, Sumit [1 ,2 ,5 ]
机构
[1] Columbia Univ, Vagelos Coll Phys & Surg, Div Nephrol, Dept Med, New York, NY 10032 USA
[2] Columbia Univ, Renal Epidemiol CURE Grp, New York, NY 10032 USA
[3] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
[4] Cleveland Clin, Lerner Res Inst, Ctr Populat Hlth Res, Cleveland, OH 44106 USA
[5] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA
关键词
clinical decision-making; donors and donation; deceased; health services and outcomes research; kidney transplantation; nephrology; organ acceptance; organ allocation; organ procurement and allocation; COLD ISCHEMIA TIME; SURVIVAL BENEFIT; PROCUREMENT; TRANSPLANTATION; PARTICIPATION; ASSOCIATION; IMPACT;
D O I
10.1111/ajt.16967
中图分类号
R61 [外科手术学];
学科分类号
摘要
Kidney transplant centers set organ offer filters enabling all candidates at their center to be bypassed during allocation of deceased donor kidneys from the UNOS Organ Center. These filters aim to increase allocation efficiency by preemptively screening out offers unlikely to be accepted. National data were used to compare filter settings of 175 centers in 2007 and in 2019. We examined characteristics of centers whose settings became increasingly restrictive over time, and associations between filter settings and organ offer acceptance. Overall, centers became more open to receiving offers over time, from a median 62% of filters open to receiving national offers in 2007 to 73% in 2019. Intravenous drug use filter settings changed most, from 63 to 153 willing centers. Centers with more open filter settings had higher transplant volume and offer acceptance ratios across all risk categories despite preemptively screening out fewer offers compared to centers with less open settings, but similar transplant rates. There was significant geographic heterogeneity in the distribution of centers with more open filter settings. Current center bypass filters may impact patients' access to transplantation without achieving their full potential for improving allocation efficiency.
引用
收藏
页码:1593 / 1602
页数:10
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