A new approach for microextraction of non-steroidal anti-inflammatory drugs from human urine samples based on in-situ deep eutectic mixture formation

被引：62

作者：

Shishov, A. Y. ^{[1
]}

Chislov, M. V. ^{[2
]}

Nechaeva, D. V. ^{[1
]}

Moskvin, L. N. ^{[1
]}

Bulatov, A. V. ^{[1
]}

机构：

[1] St Petersburg State Univ, Dept Analyt Chem, Inst Chem, St Petersburg Univ,SPbSU,SPbU, 7-9 Univ Skaya Nab, St Petersburg 199034, Russia

[2] St Petersburg State Univ, Res Pk St Petersburg Univ, Ctr Thermal Anal & Calorimetry, St Petersburg Univ,SPbSU,SPbU, 7-9 Univ Skaya Nab, St Petersburg 199034, Russia

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2018年 / 272卷

基金：

俄罗斯科学基金会;

关键词：

Microextraction; Deep eutectic solvent; Menthol; HPLC-UV; Ketoprofen and diclofenac; Human urine; LIQUID-LIQUID MICROEXTRACTION; SOLID-PHASE MICROEXTRACTION; PHARMACEUTICAL FORMULATIONS; EXTRACTION; SOLVENTS; HPLC; CHROMATOGRAPHY; MENTHOL; PLASMA;

D O I：

10.1016/j.molliq.2018.10.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new strategy for the simple, environmental-friendly and highly-available microextraction of non-steroidal anti-inflammatory drugs (NSAIDs) from human urine samples has been proposed. The procedure assumes NSAIDs separation from aqueous sample phase via in-situ forming deep eutectic mixtures based on the formation of hydrogen bond between-OH group of menthol and the oxygen atom of-COOH group of NSAIDs. The developed strategy was used for the HPLC-UV determination of ketoprofen and diclofenac in human urine samples. Under optimal experimental conditions limits of detection, calculated from a blank test, based on 3 sigma were found to be 15 mu g L-1 and 44 mu g L-1 for ketoprofen and diclofenac, respectively. The microextraction process can reach equilibrium within 1 min with extraction recovery values from 93 to 97% for both analytes. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：738 / 745

页数：8

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