Pathobiology of opisthorchiasis: an update

被引：120
作者：
Sripa, B [1 ]
机构：
[1] Khon Kaen Univ, Fac Med, Dept Pathol, Div Expt Pathol, Khon Kaen 40002, Thailand
来源：
ACTA TROPICA | 2003年 / 88卷 / 03期
关键词：
Opisthorchis viverrini; opisthorchiasis; bile duct; gall bladder; pathology; immunopathology; cholelithiasis;
D O I：
10.1016/j.actatropica.2003.08.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Opisthorchis viverrini infection is associated with several hepatobiliary diseases including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis and cholelithiasis. Pathological consequences of O. viverrini infection occur mainly in the liver, extrahepatic bile ducts, gall bladder and kidney. These pathologies have been described in both humans and experimental animals. Moreover, both experimental and epidemiological evidence strongly implicate the liver fluke infection in the etiology of cholangiocarcinoma-the bile duct cancer. This review summarizes the pathology of opisthorchiasis from literature mainly published between 1970 and the present time and, particularly, emphasizes on current concept in pathogenesis of the disease. The theme is to highlight the new era of pathogenetic study of opisthorchiasis especially on host-parasite interaction and host immune/inflammatory responses leading to tissue damage. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：209 / 220
页数：12
相关论文
共 74 条
[11]   A HIGH-FREQUENCY OF HEPATOBILIARY DISEASE AND SUSPECTED CHOLANGIOCARCINOMA ASSOCIATED WITH HEAVY OPISTHORCHIS-VIVERRINI INFECTION IN A SMALL COMMUNITY IN NORTH-EAST THAILAND [J].
ELKINS, DB ;
HASWELLELKINS, MR ;
MAIRIANG, E ;
MAIRIANG, P ;
SITHITHAWORN, P ;
KAEWKES, S ;
BHUDHISAWASDI, V ;
UTTARAVICHIEN, T .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (05) :715-719
[12]   BILIARY TRACT CHANGES IN OPISTHORCHIASIS [J].
EVANS, H ;
BOURGEOIS, CH ;
COMER, DS ;
KESCHAMRAS, N .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1971, 20 (05) :667-+
[13]  
Figueiredo C, 2002, J NATL CANCER I, V94, P1680, DOI 10.1093/jnci/94.22.1680
[14]   OPISTHORCHIS-VIVERRINI - PATHOGENESIS OF INFECTION IN IMMUNODEPRIVED HAMSTERS [J].
FLAVELL, DJ ;
FLAVELL, SU .
PARASITE IMMUNOLOGY, 1986, 8 (05) :455-466
[15]  
Gibson JB, 1971, PATHOLOGY PROTOZOAL, P546
[16]  
HARINASUTA T, 1984, DRUG RES, V34, P1167
[17]  
HASWELLELKINS MR, 1991, CLIN EXP IMMUNOL, V84, P213, DOI 10.1111/j.1365-2249.1991.tb08151.x
[18]   Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni:: IFN-γ is associated with protection against fibrosis and TNF-α with aggravation of disease [J].
Henri, S ;
Chevillard, C ;
Mergani, A ;
Paris, P ;
Gaudart, J ;
Camilla, C ;
Dessein, H ;
Montero, F ;
Elwali, NEMA ;
Saeed, OK ;
Magzoub, M ;
Dessein, AJ .
JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :929-936
[19]   PERITONEOSCOPIC FINDINGS IN 203 PATIENTS WITH OPISTHORCHIS-VIVERRINI INFECTION [J].
HITANANT, S ;
TRONG, DTN ;
DAMRONGSAK, C ;
CHINAPAK, O ;
BOONYAPISIT, S ;
PLENGVANIT, U ;
VIRANUVATTI, V .
GASTROINTESTINAL ENDOSCOPY, 1987, 33 (01) :18-20
[20]   The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda) [J].
Hoerauf, A ;
Kruse, S ;
Brattig, NW ;
Heinzmann, A ;
Mueller-Myhsok, B ;
Deichmann, KA .
MICROBES AND INFECTION, 2002, 4 (01) :37-42
12345678