Association between affective temperaments and mood features in bipolar disorder II: The role of insomnia and chronobiological rhythms desynchronization

被引：12

作者：

Palagini, Laura ^{[1
]}

Miniati, Mario ^{[1
]}

Caruso, Danila ^{[1
]}

Massa, Lucia ^{[1
]}

Novi, Martina ^{[1
]}

Pardini, Francesco ^{[1
]}

Salarpi, Gianluca ^{[1
]}

Pini, Stefano ^{[1
]}

Marazziti, Donatella ^{[1
]}

Etain, Bruno ^{[2
]}

Riemann, Dieter ^{[3
]}

机构：

[1] Univ Pisa, Azienda Osped Univ Pisana AUOP, Dept Clin & Expt Med, Psychiat Sect, Via Roma 67, I-56100 Pisa, Italy

[2] Univ Paris Diderot, GH St Louis, AP HP, Lariboisiere F Widal,Sorbonne Paris Cite,Univ Par, Paris, France

[3] Univ Freiburg, Med Ctr, Dept Psychiat & Psychotherapy, Fac Med, Freiburg, Germany

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2020年 / 266卷

关键词：

Bipolar disorder; Affective temperaments; Chronobiological rhythms; Insomnia; TEMPS-A; CIRCADIAN PREFERENCE; SLEEP QUALITY; METAANALYSIS; DEPRESSION; SYMPTOMS; NEUROPSYCHIATRY; RECOGNITION; DISTURBANCE; CHRONOTYPE;

D O I：

10.1016/j.jad.2020.01.134

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: : Bipolar disorders are complex disorders involving the interaction of multiple factors. Affective temperaments, insomnia, and chronobiological rhythms desynchronization may all contribute to bipolar disorder. Since there is a paucity of research examining this topic we aimed to study how they are interrelated and collectively associated with clinical features of bipolar disorder. Method: : One-hundred patients with Bipolar Disorder type II depressive episode with and without mixed features were recruited and compared. Subjects were evaluated with SCID -5, the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), the Insomnia Severity Index (ISI), and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) while evaluating depressive (Beck Depression Inventory-BDI-II) and manic (Young Mania Rating Scale-YMRS) symptoms. Logistic regression and mediation analyses were conducted. Results: : Subjects with mixed features showed a higher scores in both insomnia and chronobiological rhythms scores. When considering affective temperaments not only depressive, cyclothymic and irritable temperaments predicted mood symptoms but also insomnia (depressive symptoms O.R. 4.17, p = 0.043) and chronobiological sleep de-synchronization (manic symptoms O.R. 8.69, p = 0.001). Insomnia symptoms and chronobiological alterations mediated the association between affective temperaments and mood symptoms. Limitations: : the cross-sectional design limited any causal interpretation. Conclusion: : Subjects with mixed features showed a greater severity of insomnia and chronobiological rhythm de-synchronization compared to subjects without. Insomnia and chronobiological alterations may contribute to mood disorders together with affective temperaments in a complex interplay also mediating their effect on mood. Preventive strategies for bipolars should also act on the dysregulation of sleep and circadian rhythms.

引用

页码：263 / 272

页数：10

共 71 条

[1] TEMPS-A: progress towards validation of a self-rated clinical version of the temperament evaluation of the Memphis, Pisa, Paris, and San Diego autoquestionnaire [J].