Chitosan biopolymer, its derivatives and potential applications in nano-therapeutics: A comprehensive review

被引：31

作者：

Mukhtar, Mahwash ^{[1
]}

Fenyes, Eszter ^{[1
]}

Bartos, Csilla ^{[1
]}

Zeeshan, Mahira ^{[2
]}

Ambrus, Rita ^{[1
]}

机构：

[1] Univ Szeged, Interdisciplinary Excellence Ctr, Inst Pharmaceut Technol & Regulatory Affairs, Eotvos St 6, H-6720 Szeged, Hungary

[2] Quaid I Azam Univ, Dept Pharm, Fac Biol Sci, Islamabad, Pakistan

来源：

EUROPEAN POLYMER JOURNAL | 2021年 / 160卷

关键词：

Biopolymer; Chitosan; Gene delivery; Mucoadhesion; Nanoparticles; Nasal; Pulmonary; Transdermal; IN-VITRO EVALUATION; DRUG-DELIVERY; THIOLATED CHITOSAN; N; N-TRIMETHYL CHITOSAN; TARGETED DELIVERY; TRANSDERMAL DELIVERY; TRIMETHYL CHITOSAN; GLYCOL CHITOSAN; ORAL DELIVERY; IMMUNE-RESPONSES;

D O I：

10.1016/j.eurpolymj.2021.110767

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Chitosan (CS) is a natural biopolymer used frequently in drug delivery because of its biodegradability and biocompatibility. Several derivatives of CS have also been synthesized to improve the mucoadhesion and solubility of the nascent CS. The nano and micro particles are reported to have enhanced drug bioavailability, solubility and permeation. Recently, there is an advancement in the active targeted drug and gene delivery using CS because of its tunable surface modifications. This review focuses on CS and its chemically modified structures along with their different nanostructures with examples from the most exploited routes of administration. Herein, the functionalization of CS nanoparticles has also been enlisted along with the use of CS in the immunotherapy as vaccine carriers. Beside, few patents, ongoing clinical trials and already marketed CS-based products are also enlisted.

引用

页数：20

共 208 条

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