Stem cells and early lineage development

被引：245

作者：

Rossant, Janet ^{[1
]}

机构：

[1] Univ Toronto, Dept Mol Genet, Hosp Sick Children, Res Inst,Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

来源：

CELL | 2008年 / 132卷 / 04期

关键词：

D O I：

10.1016/j.cell.2008.01.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent derivation of pluripotent stem cell lines from a number of different sources, including reprogrammed adult somatic cells, raises the issue of the developmental equivalence of these different pluripotent states. At least two different states representing the epiblast progenitors in the blastocyst and the pluripotent progenitors of the later gastrulating embryo have been recognized. Understanding the initial developmental status of the different pluripotent lines is critical for defining starting conditions for differentiation toward therapeutically relevant cell types.

引用

页码：527 / 531

页数：5

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