Fabrication of poly(ε-caprolactone)/keratin nanofibrous mats as a potential scaffold for vascular tissue engineering

被引：45

作者：

Li, Yanmei ^{[1
]}

Wang, Yanfang ^{[1
]}

Ye, Jingjie ^{[1
]}

Yuan, Jiang ^{[1
]}

Xiao, Yinghong ^{[1
]}

机构：

[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 68卷

基金：

中国国家自然科学基金;

关键词：

Keratin; Cytocompatibility; Blood compatibility; Electrospinning; Poly(epsilon-caprolactone); KERATIN HYDROGELS SUPPORT; BIOMEDICAL APPLICATIONS; HUMAN HAIR; BIOMATERIALS; PROLIFERATION; MODEL; POLY(L-LACTIDE-CO-EPSILON-CAPROLACTONE); POLYURETHANE; REGENERATION; CULTIVATION;

D O I：

10.1016/j.msec.2016.05.117

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The natural abundance of cell adhesion sequences, RGD (Arg-Gly-Asp) and LDV (Leu-Asp-Val) in the keratins make them suitable as biomaterials for tissue engineering applications. Herein, keratins were coelectrospun with poly(epsilon-caprolactone)(PCL) at the ratio of 9/1, 8/2, and 7/3 to afford nanofibrous mats. The resulting mats were surface characterized by ATR-FFIR, SEM, WCA, and XPS. Cell attachment data showed that NIH 3T3 cells adhered more to the PCL/keratin nanofibrous mats than the pristine PCL mats. The MTT assay revealed that the PCL/keratin mats had improved cell viability. The blood clotting time test (APTT, PT, and TT) indicated the PCL/keratin mats exerted good blood compatibility. These mats would be a good candidate as a scaffold for vascular tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：177 / 183

页数：7

共 35 条

[21] The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves [J].