Conducting Polymer Microcups for Organic Bioelectronics and Drug Delivery Applications

被引:31
作者
Antensteiner, Martin [1 ]
Khorrami, Milad [1 ]
Fallahianbijan, Fatemeh [2 ]
Borhan, Ali [2 ]
Abidian, Mohammad Reza [1 ]
机构
[1] Univ Houston, Dept Biomed Engn, 3517 Cullen Blvd,Room 2027, Houston, TX 77204 USA
[2] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA
基金
美国国家卫生研究院;
关键词
conducting polymers; drug release; microelectrodes; neural interfaces; ELECTROCHEMICALLY CONTROLLED-RELEASE; NEURAL MICROELECTRODE ARRAYS; CEREBRAL-CORTEX; NOBEL LECTURE; INTERFACES; DEVICES; NANOTUBES; RESPONSES; TISSUE; POLY(3,4-ETHYLENEDIOXYTHIOPHENE);
D O I
10.1002/adma.201702576
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An ideal neural device enables long-term, sensitive, and selective communication with the nervous system. To accomplish this task, the material interface should mimic the biophysical and the biochemical properties of neural tissue. By contrast, microfabricated neural probes utilize hard metallic conductors, which hinder their long-term performance because these materials are not intrinsically similar to soft neural tissue. This study reports a method for the fabrication of monodisperse conducting polymer microcups. It is demonstrated that the physical surface properties of conducting polymer microcups can be precisely modulated to control electrical properties and drug-loading/release characteristics.
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页数:11
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