[18F]FDG and [18F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus

被引：17

作者：

Reijrink, M. ^{[1
,2
]}

de Boer, S. A. ^{[1
]}

te Velde-Keyzer, C. A. ^{[3
]}

Sluiter, J. K. E. ^{[1
]}

Pol, R. A. ^{[4
]}

Heerspink, H. J. L. ^{[5
]}

Greuter, M. J. W. ^{[6
,7
]}

Hillebrands, J. L. ^{[2
]}

Mulder, D. J. ^{[1
]}

Slart, R. H. J. A. ^{[7
,8
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Vasc Med, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Div Pathol, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Vasc & Transplant Surg, Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Med Imaging Ctr, Dept Radiol, Groningen, Netherlands

[7] Univ Twente, Fac Sci & Technol, Biomed Photon Imaging, Enschede, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands

来源：

JOURNAL OF NUCLEAR CARDIOLOGY | 2022年 / 29卷 / 04期

关键词：

Inflammation; diabetes; atherosclerosis; PET; CT; vascular imaging; INFLAMMATION; PLAQUE; CALCIFICATION;

D O I：

10.1007/s12350-021-02781-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background While [F-18]-fluordeoxyglucose ([F-18]FDG) uptake is associated with arterial inflammation, [F-18]-sodium fluoride ([F-18]NaF) is a marker for arterial micro-calcification. We aimed to investigate the prospective correlation between both PET markers over time and whether they are prospectively ([F-18]FDG) and retrospectively ([F-18]NaF) related to progression of systemic arterial disease in a longitudinal study in patients with type 2 diabetes mellitus (T2DM). Methods Baseline [F-18]FDG PET/Low Dose (LD) Computed Tomography (CT) scans of ten patients with early T2DM without cardiovascular history (70% men, median age 63 years) were compared with five-year follow-up [F-18]NaF/LDCT scans. Systemic activity was expressed as mean target-to-background ratio (meanTBR) by dividing the maximal standardized uptake value (SUVmax) of ten arteries by SUVmean of the caval vein. CT-assessed macro-calcifications were scored visually and expressed as calcified plaque (CP) score. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). Five-year changes were expressed absolutely with delta (Delta) and relatively with %change. Results Baseline meanTBR[F-18]FDG was strongly correlated with five-year follow-up meanTBR[F-18]NaF (r = 0.709, P = .022). meanTBR[F-18]NaF correlated positively with Delta CPscore, CPscore at baseline, and follow-up (r = 0.845, P = .002 and r = 0.855, P = .002, respectively), but not with %change in CPscore and PWV. Conclusion This proof-of-concept study demonstrated that systemic arterial inflammation is an important pathogenetic factor in systemic arterial micro-calcification development.

引用

页码：1702 / 1709

页数：8