Chemoenzymatic synthesis of N-Boc protected (2S,3R)-3-hydroxy-3-methylproline

被引：7
作者：
Haddad, M [1 ]
Larchevêque, M [1 ]
机构：
[1] Ecole Natl Super Chim Paris, CNRS, Synth Organ Lab, F-75231 Paris, France
来源：
TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 13期
关键词：
D O I：
10.1016/j.tetasy.2005.05.030
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
N-Boc protected 3-hydroxy-2-hydroxymetliyl-3-methylpyrrolidine was kinetically resolved by acylation in an organic solvent catalyzed by Pseudomonas fluorescens lipase to give the corresponding acetate and residual diol in 14 E. Further selective oxidation afforded the title compound in high diastereo- and enantioselectivity. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：2243 / 2247
页数：5
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