Objective: this study was designed to analyze the effect of the collaborative nursing model on the self-nursing ability, hemodialysis compliance, and quality of life of patients on hemodialysis. Methods: 121 patients with end-stage renal disease (ESRD) admitted to our hospital were included as the study objects, retrospectively analyzed, and divided into 2 groups based on the nursing method used. While the control group was routinely nursed, the observation group was subjected to the collaborative nursing model, and the 2 groups were compared in terms of their scores from the exercise of self-nursing agency scale (MCA), hemodialysis compliance, short form 36 health survey questionnaire (SF-36), and satisfaction after nursing. Results: (1) The scores of self-concept, self-nursing sense of responsibility, self-nursing skills, health knowledge level, and self-nursing ability in the observation group after the intervention were (29.98 +/- 2.15), (32.58 +/- 2.38), (40.28 +/- 4.05), (47.89 +/- 4.59), (116.99 +/- 5.88), respectively, which were higher than the corresponding scores in the control group (P<0.05). (2) The scores of compliance with the hemodialysis program, medication, liquid intake, dieting and hemodialysis in the observation group after the intervention were (21.19 +/- 1.29), (21.45 +/- 1.58), (20.59 +/- 1.63), (17.98 +/- 1.88), (86.63 +/- 1.88), respectively, which were higher than the corresponding scores in the control group (P<0.05). (3) The scores of mental health, interpersonal relations, social function, exercise, overall health, body pain, physiological role, and physiological function in the observation group after the intervention were (92.25 +/- 0.12), (91.02 +/- 2.55), (90.18 +/- 1.29), (92.28 +/- 2.6), (93.29 +/- 1.2), (92.13 +/- 2.88), (93.26 +/- 2.59), (95.63 +/- 1.29), respectively, which were higher than the corresponding scores in the control group (P<0.05). Conclusion: The collaborative nursing model can improve the self-nursing ability, hemodialysis compliance, and quality of life (QOL) of patients on hemodialysis.