Telomerase activity in thyroid tumors

被引：1
|
作者：
Onoda, N
Ishikawa, T
Yoshikawa, K
Sugano, S
Kato, Y
Sowa, M
Chung, KHYS
机构：
[1] Osaka City Univ, Sch Med, Dept Oncol, Inst Geriatr & Med Sci,Abeno Ku, Osaka 5458585, Japan
[2] Osaka City Univ, Sch Med, Dept Surg 1, Abeno Ku, Osaka 5458585, Japan
[3] Osaka City Gen Hosp, Miyakojima Ku, Osaka 534, Japan
来源：
ONCOLOGY REPORTS | 1998年 / 5卷 / 06期
关键词：
thyroid cancer; telomerase activity;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We quantified telomerase activities in thyroid tumors by a telomeric-repeat-amplification-protocol-based assay in an attempt to determine its clinical significance. Telomerase activity was detected in 10 of 18 (55.6%) malignant tumors, but in none of the four benign lesions, and the level of telomerase activity correlated significantly with the progression of the clinical stages. High activity was determined in 4 (80%) of 5 metastatic lesions in the lymph nodes. Five (45.5%) of 11 non-tumoral specimens from malignant cases showed telomerase activity, while none of the four from benign cases did. In conclusion, the determination of telomerase activity might be useful in determining the existence and progression of thyroid cancer.
引用
收藏
页码：1447 / 1450
页数：4
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