Oxaphosphole-Based Monophosphorus Ligands for Palladium-Catalyzed Amination Reactions

被引：54
作者：
Rodriguez, Sonia [1 ]
Qu, Bo [1 ]
Haddad, Nizar [1 ]
Reeves, Diana C. [1 ]
Tang, Wenjun [1 ]
Lee, Heewon [1 ]
Krishnamurthy, Dhileepkumar [1 ]
Senanayake, Chris H. [1 ]
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Chem Dev, Ridgefield, CT 06877 USA
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 04期
关键词：
N-arylamination; C-N coupling; palladium; CROSS-COUPLING REACTIONS; C-N; SUZUKI-MIYAURA; ARYL CHLORIDES; EFFICIENT LIGAND; HETEROARYL; BROMIDES; ARYLATIONS; PHOSPHINES; IODIDES;
D O I：
10.1002/adsc.201000878
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel class of C-2-substituted oxaphosphole-based monophosphines 1-4 has been synthesized. Palladium complexes derived from these ligands and their C-2-unsubstituted analogs provide general catalysts for amination reactions of challenging aryl and heteroaryl halides with sterically hindered anilines and alkylamines.
引用
收藏
页码：533 / 537
页数：5
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