Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications

被引：169

作者：

Sonawane, Ravindra P. ^{[1
]}

Jheengut, Vishal ^{[1
]}

Rabalakos, Constantinos ^{[1
]}

Larouche-Gauthier, Robin ^{[1
]}

Scott, Helen K. ^{[1
]}

Aggarwal, Varinder K. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 16期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

borates; chirality; natural products; olefination; stereogenic centers; ALGA SPOROCHNUS-BOLLEANUS; MARINE ALGA; ASYMMETRIC-SYNTHESIS; FISH DETERRENT; ALLYLIC SUBSTITUTIONS; MIGRATORY APTITUDES; ANTAGONIST LY426965; SECONDARY ALCOHOLS; CARBON CENTERS; ALKYL-GROUPS;

D O I：

10.1002/anie.201008067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pin it down: A range of substrates that bear versatile functional groups with quaternary stereogenic centers have been prepared with very high enantioselectivity from tertiary boronic esters (see scheme; Cb=N,N-diisopropylcarbamoyl, pin=pinacolato). The preparation of allylboronic esters bearing contiguous quaternary and tertiary stereogenic centers, and applications to natural product synthesis are also reported. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3760 / 3763

页数：4

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