Synthesis and Antibacterial Activity of New N-Substituted Hexahydroquinolinone Derivatives and X-Ray Crystallographic Studies

被引：5

作者：

Vinoth, Nangagoundan ^{[1
]}

Kalaiarasi, Chinnasamy ^{[2
]}

Kumaradhas, Poomani ^{[2
]}

Vadivel, Pullar ^{[3
]}

Lalitha, Appaswami ^{[1
]}

机构：

[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India

[2] Periyar Univ, Dept Phys, Salem 636011, Tamil Nadu, India

[3] Salem Sowdeswari Coll, Dept Chem, Salem 636010, Tamil Nadu, India

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 09期

关键词：

Antibacterial activity; cyclocondenzation reaction; hexahydroquinolinone; knovenegel adduct; piperidine;

D O I：

10.1002/slct.201904565

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel series of 2-amino-4-aryl-7,7-dimethyl-5-oxo-1-(phenylamino)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile derivatives has been designed using aryl aldehydes, 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enone (phenylhydrazone of dimedone) and malononitrile with piperidine at room temperature. The structures of the synthesized compounds have been well elucidated by various spectroscopic techniques and X-ray crystal diffraction studies. Selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.

引用

收藏

页码：2696 / 2700

页数：5

相关论文

共 31 条

[1] Visible-Light-Promoted and One-Pot Synthesis of Phenanthridines and Quinolines from Aldehydes and O-Acyl Hydroxylamine [J].

An, Xiao-De ;

Yu, Shouyun .

ORGANIC LETTERS, 2015, 17 (11) :2692-2695

[2] QUINOLINE: A DIVERSE THERAPEUTIC AGENT [J].

Anjali ;

Pathak, Dharampal ;

Singh, Divya .

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (01) :1-13

[3] Synthesis, Antimicrobial Activities, and Molecular Docking Studies of Dihydrotriazine Derivatives Bearing a Quinoline Moiety [J].

Bai, Xueqian ;

Chen, Ying ;

Liu, Zhe ;

Zhang, Linhao ;

Zhang, Tianyi ;

Feng, Bo .

CHEMISTRY & BIODIVERSITY, 2019, 16 (06)

[4] Tafenoquine for travelers′ malaria: evidence, rationale and recommendations [J].

Baird, J. Kevin .

JOURNAL OF TRAVEL MEDICINE, 2018, 25

[5] Structural modifications of quinoline-based antimalarial agents: Recent developments [J].

Bawa, Sandhya ;

Kumar, Suresh ;

Drabu, Sushma ;

Kumar, Rajiv .

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2010, 2 (02) :64-71

[6]

Changmin K., 2018, J NANOSCI NANOTECHNO, V18, P7105

[7] Rh(III)-Catalyzed C(8)-H Activation of Quinoline N-Oxides: Regioselective C-Br and C-N Bond Formation [J].

Dhiman, Ankit Kumar ;

Gupta, Shiv Shankar ;

Sharma, Ritika ;

Kumar, Rakesh ;

Sharma, Upendra .

JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (20) :12871-12880

[8] Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives [J].

El-Sayed, Nahed N. E. ;

Almaneai, Norah M. ;

Ben Bacha, Abir ;

Al-Obeed, Omar ;

Ahmad, Rehan ;

Abdulla, Maha ;

Alafeefy, Ahmed M. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019, 34 (01) :672-683

[9]

Freedman D. O., 2019, J TRAVEL MED, V26, P1

[10] Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents [J].

Fu, Hai-Gen ;

Li, Zhi-Wen ;

Hu, Xin-Xin ;

Si, Shu-Yi ;

You, Xue-Fu ;

Tang, Sheng ;

Wang, Yan-Xiang ;

Song, Dan-Qing .

MOLECULES, 2019, 24 (03)

← 1 2 3 4 →