A role for taurine in mitochondrial function

被引：117

作者：

Hansen, Svend Hoime ^{[1
]}

Andersen, Mogens Larsen ^{[2
]}

Cornett, Claus ^{[3
]}

Gradinaru, Robert ^{[4
]}

Grunnet, Niels ^{[5
]}

机构：

[1] Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Fac Life Sci, Dept Food Sci, DK-1958 Frederiksberg C, Denmark

[3] Univ Copenhagen, Dept Analyt Chem, Fac Pharmaceut Sci, DK-2100 Copenhagen, Denmark

[4] Alexandru Ioan Cuza Univ, Dept Chem, Iasi 700506, Romania

[5] Univ Copenhagen, Dept Biomed Sci, Fac Hlth Sci, DK-2200 Copenhagen N, Denmark

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2010年 / 17卷

关键词：

ACYL-COA DEHYDROGENASES; FREE AMINO-ACIDS; OXIDATIVE-PHOSPHORYLATION; DIABETIC COMPLICATIONS; SKELETAL-MUSCLE; CELL-TYPES; RAT; CARNOSINE; PROTEIN; DIPEPTIDES;

D O I：

10.1186/1423-0127-17-S1-S23

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25 degrees C) and 8.6 (37 degrees C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.

引用

页数：8

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