Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis

被引：163

作者：

Gori, Andrea ^{[1
,2
]}

Tincati, Camilla ^{[2
]}

Rizzardini, Giuliano ^{[3
]}

Torti, Carlo ^{[4
]}

Quirino, Tiziana ^{[5
]}

Haarman, Monique ^{[6
]}

Ben Amor, Kaouther ^{[6
]}

van Schaik, Jacqueline ^{[6
]}

Vriesema, Aldwin ^{[6
]}

Knol, Jan ^{[6
]}

Marchetti, Giulia ^{[7
]}

Welling, Gjalt ^{[8
]}

Clerici, Mario ^{[9
]}

机构：

[1] Univ Milano Bicocca, Inst Internal Med, Div Infect Dis, San Gerardo Hosp, Monza, Italy

[2] Univ Milan, Dept Internal Med, Clin Infect Dis, San Paolo Hosp, Milan, Italy

[3] Luigi Sacco Hosp, Div Infect Dis 1, Milan, Italy

[4] Univ Brescia, Clin Infect Dis, Brescia, Italy

[5] Busto Arsizio Hosp, Infect Dis Unit, Busto Arsizio, Italy

[6] Numico Res BV, Wageningen, Netherlands

[7] Univ Milan, Dept Clin Sci, Luigi Sacco Hosp, Milan, Italy

[8] Univ Groningen, Dept Med Microbiol, Univ Med Ctr Groningen, Groningen, Netherlands

[9] Univ Milan, Dept Biomed Sci & Technol, I-20133 Milan, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 02期

关键词：

D O I：

10.1128/JCM.01729-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.

引用

页码：757 / 758

页数：2

共 17 条

[11] Interactions between commensal intestinal bacteria and the immune system [J].