Pd-catalyzed Cross-Coupling of α-(Acyloxy)-tri-n-butylstannanes with Alkenyl, Aryl, and Heteroaryl Electrophiles

被引：41

作者：

Goli, Mohan

He, Anyu

Felck, J. R. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 02期

关键词：

ACYL CHLORIDES; AMINOSTANNANES; KETONES; ACID;

D O I：

10.1021/ol102863u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic and scalemic alpha-(acyloxy)-tri-n-butylstannanes undergo Pd-catalyzed cross-couplings with alkenyl/aryl/heteroaryl iodides, bromides, and triflates in moderate to good yields in THF at 45 degrees C. Simple aryl iodides and unprotected aza-arenes, two classes of electrophiles that typically react sluggishly, are also good substrates. Cross-couplings proceed with retention of configuration at the alkenyl and stannyl-substituted stereocenters.

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页码：344 / 346

页数：3

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