Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy

被引：103

作者：

Ho, Chao-Chi ^{[1
,2
,3
]}

Kuo, Sung-Hsin ^{[2
,4
]}

Huang, Pei-Hsin ^{[2
,5
]}

Huang, Hsin-Yi ^{[2
,5
]}

Yang, Chih-Hsin ^{[2
,4
]}

Yang, Pan-Chyr ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Pathol, Taipei, Taiwan

来源：

LUNG CANCER | 2008年 / 59卷 / 01期

关键词：

caveolin-1; lung cancer; drug resistance; prognosis; pathology; survival;

D O I：

10.1016/j.lungcan.2007.07.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolin-1 was up-regulated in different drug-resistant cancer cell tines and was suggested to confer drug resistance by different mechanisms. However, the relation of caveolin-1 expression and the clinical response to chemotherapy and prognosis in non-small cell lung cancer (NSCLC) remains unknown. Total 73 NSCLC (stages IIIB and IV) patients who received gemcitabine-based chemotherapy and also had tumour specimens available before treatment were assessed for caveolin-1 expression using immunohistochemistry. Immunoreactivity of caveolin-1 was correlated with the response to chemotherapy, the clinicopathologic features, and the progression-free survival (PFS) and overall survival (OS) of all patients. Positive caveolin-1 immunostaining was found in 12 (16.4%) of the 73 patients. Eight of the twelve had disease progression and the other four patients remained stable after chemotherapy. Patients with caveolin-1 expression had a significantly lower response rate (complete or partial response, 0% versus 37.7%; P=0.01) and a poor PFS and OS (median survival time: PFS, 4.6 months versus 6.1 months, P=0.005; OS, 7.0 months versus 14 months, P < 0.001) than those without caveolin-1 expression. Moreover, multivariate analyses indicated that caveolin-1 positivity was an independent prognostic factor for disease-free survival (DFS) (P=0.003) and CS (P=0.008), respectively. Caveolin-1 expression significantly correlated with drug resistance and a poor prognosis in advanced NSCLC patients treated with gemcitabine-based chemotherapy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：105 / 110

页数：6

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